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BL1S6_CAEEL
ID   BL1S6_CAEEL             Reviewed;         106 AA.
AC   O01822; J7JQW0;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 5.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 6;
DE            Short=BLOC-1 subunit 6;
DE   AltName: Full=Pallid protein homolog;
GN   Name=glo-2; ORFNames=F57C9.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, SUBUNIT, INTERACTION WITH
RP   BLOS-1 AND BLOS-4, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=22916203; DOI=10.1371/journal.pone.0043043;
RA   Hermann G.J., Scavarda E., Weis A.M., Saxton D.S., Thomas L.L., Salesky R.,
RA   Somhegyi H., Curtin T.P., Barrett A., Foster O.K., Vine A., Erlich K.,
RA   Kwan E., Rabbitts B.M., Warren K.;
RT   "C. elegans BLOC-1 Functions in Trafficking to Lysosome-Related Gut
RT   Granules.";
RL   PLoS ONE 7:E43043-E43043(2012).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in gut granule biogenesis.
CC       {ECO:0000269|PubMed:22916203}.
CC   -!- SUBUNIT: Homodimer (isoform 1). Component of the biogenesis of
CC       lysosome-related organelles complex-1 (BLOC-1) composed at least of
CC       blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1 (By
CC       similarity). Isoform 1 interacts with blos-1 and blos-4. {ECO:0000250,
CC       ECO:0000269|PubMed:22916203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22916203}. Endosome
CC       {ECO:0000269|PubMed:22916203}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in developing embryos in intestinal
CC       cells (at protein level). {ECO:0000269|PubMed:22916203}.
CC   -!- SIMILARITY: Belongs to the BLOC1S6 family. {ECO:0000305}.
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DR   EMBL; JX401287; AFQ55889.1; -; mRNA.
DR   EMBL; JX401288; AFQ55890.1; -; mRNA.
DR   EMBL; FO080263; CCD62434.2; -; Genomic_DNA.
DR   RefSeq; NP_001293460.1; NM_001306531.1.
DR   RefSeq; NP_491461.3; NM_059060.3.
DR   AlphaFoldDB; O01822; -.
DR   SMR; O01822; -.
DR   BioGRID; 51187; 3.
DR   ComplexPortal; CPX-479; Bloc-1 complex.
DR   STRING; 6239.F57C9.3a; -.
DR   PaxDb; O01822; -.
DR   PRIDE; O01822; -.
DR   EnsemblMetazoa; F57C9.3b.1; F57C9.3b.1; WBGene00019010.
DR   GeneID; 186447; -.
DR   KEGG; cel:CELE_F57C9.3; -.
DR   UCSC; F57C9.3; c. elegans.
DR   CTD; 186447; -.
DR   WormBase; F57C9.3b; CE46926; WBGene00019010; glo-2.
DR   eggNOG; ENOG502TJ5Z; Eukaryota.
DR   InParanoid; O01822; -.
DR   OrthoDB; 1811518at2759; -.
DR   PRO; PR:O01822; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00019010; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; O01822; baseline.
DR   GO; GO:0031082; C:BLOC complex; IC:ComplexPortal.
DR   GO; GO:0031083; C:BLOC-1 complex; TAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; IMP:UniProtKB.
DR   GO; GO:1904757; P:positive regulation of gut granule assembly; IC:ComplexPortal.
DR   GO; GO:0090316; P:positive regulation of intracellular protein transport; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endosome; Reference proteome.
FT   CHAIN           1..106
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 6"
FT                   /id="PRO_0000420199"
FT   REGION          78..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   106 AA;  11953 MW;  F072DB7C4F5A3978 CRC64;
     MSNTEHNVES KNVTDTLDEI LRLQEDIQAR IGSSNHNLET NFESIKDFVS RAHAYIPILN
     QISKDMIEIC ERTQALKKKT SQLELSDTNI EDGSTTSTPT TTNKSQ
 
 
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