BL1S6_RAT
ID BL1S6_RAT Reviewed; 172 AA.
AC Q4V8A6;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 6;
DE Short=BLOC-1 subunit 6;
DE AltName: Full=Pallid protein homolog;
DE AltName: Full=Pallidin;
GN Name=Bloc1s6; Synonyms=Pldn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16760431; DOI=10.1091/mbc.e06-02-0103;
RA Salazar G., Craige B., Styers M.L., Newell-Litwa K.A., Doucette M.M.,
RA Wainer B.H., Falcon-Perez J.M., Dell'Angelica E.C., Peden A.A., Werner E.,
RA Faundez V.;
RT "BLOC-1 complex deficiency alters the targeting of adaptor protein complex-
RT 3 cargoes.";
RL Mol. Biol. Cell 17:4014-4026(2006).
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC May play a role in intracellular vesicle trafficking, particularly in
CC the vesicle-docking and fusion process (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Octamer composed of one copy each BLOC1S1, BLOC1S2,
CC BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8.
CC The BLOC-1 complex associates with the AP-3 protein complex and
CC membrane protein cargos. Interacts with BLOC1S4, BLOC1S5,
CC DTNBP1/BLOC1S7, F-actin, SNAP25 isoform 1 and isoform 2, SNAP47 and
CC STX12 (By similarity). Component of the biogenesis of lysosome-related
CC organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3,
CC BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8.
CC {ECO:0000250, ECO:0000269|PubMed:16760431}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UL45}.
CC Membrane {ECO:0000250|UniProtKB:Q9UL45}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9UL45}. Note=It can exist as a soluble protein
CC as well as a peripheral membrane protein.
CC {ECO:0000250|UniProtKB:Q9UL45}.
CC -!- SIMILARITY: Belongs to the BLOC1S6 family. {ECO:0000305}.
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DR EMBL; CH473949; EDL80048.1; -; Genomic_DNA.
DR EMBL; BC097469; AAH97469.1; -; mRNA.
DR RefSeq; NP_001020885.1; NM_001025714.1.
DR AlphaFoldDB; Q4V8A6; -.
DR SMR; Q4V8A6; -.
DR STRING; 10116.ENSRNOP00000052934; -.
DR jPOST; Q4V8A6; -.
DR PaxDb; Q4V8A6; -.
DR PRIDE; Q4V8A6; -.
DR GeneID; 317630; -.
DR KEGG; rno:317630; -.
DR UCSC; RGD:1310208; rat.
DR CTD; 26258; -.
DR RGD; 1310208; Bloc1s6.
DR eggNOG; ENOG502RZNC; Eukaryota.
DR HOGENOM; CLU_115118_1_0_1; -.
DR InParanoid; Q4V8A6; -.
DR OMA; MMSDVKR; -.
DR OrthoDB; 1509390at2759; -.
DR PhylomeDB; Q4V8A6; -.
DR TreeFam; TF325188; -.
DR Reactome; R-RNO-432722; Golgi Associated Vesicle Biogenesis.
DR PRO; PR:Q4V8A6; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Proteomes; UP000234681; Chromosome 3.
DR Bgee; ENSRNOG00000037160; Expressed in quadriceps femoris and 19 other tissues.
DR Genevisible; Q4V8A6; RN.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISO:RGD.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; ISS:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:RGD.
DR GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR GO; GO:0007596; P:blood coagulation; ISO:RGD.
DR GO; GO:0035646; P:endosome to melanosome transport; ISS:UniProtKB.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0046907; P:intracellular transport; IBA:GO_Central.
DR GO; GO:0030318; P:melanocyte differentiation; ISO:RGD.
DR GO; GO:0032402; P:melanosome transport; ISS:UniProtKB.
DR GO; GO:0061025; P:membrane fusion; ISO:RGD.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0043473; P:pigmentation; ISO:RGD.
DR GO; GO:0032816; P:positive regulation of natural killer cell activation; ISO:RGD.
DR GO; GO:0050942; P:positive regulation of pigment cell differentiation; ISS:UniProtKB.
DR GO; GO:0033299; P:secretion of lysosomal enzymes; ISO:RGD.
DR InterPro; IPR017242; BLOC-1_pallidin.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PIRSF; PIRSF037609; BLOC-1_complex_pallidin; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..172
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 6"
FT /id="PRO_0000420191"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 19703 MW; 252CB5DFB26A613E CRC64;
MNVPVPPPPD GVLTGPSDSL EAGEPTPGLS DRSPDEGLIE DLALEDRAVE HLVGGLLSHY
LPDLQRSKRA LQELTQNQVV LLDTLEQEIS KFKECHSMLD INALFTEAKH YHAKLVTIRK
EMLLLHEKTS KLKKRALKLQ QQRQKEELER EQQREREFER EKQLTAKPAK RT
