SYH1_BACAN
ID SYH1_BACAN Reviewed; 425 AA.
AC Q81N41; Q6HWA1; Q6KQF2;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Histidine--tRNA ligase 1 {ECO:0000255|HAMAP-Rule:MF_00127};
DE EC=6.1.1.21 {ECO:0000255|HAMAP-Rule:MF_00127};
DE AltName: Full=Histidyl-tRNA synthetase 1 {ECO:0000255|HAMAP-Rule:MF_00127};
DE Short=HisRS 1 {ECO:0000255|HAMAP-Rule:MF_00127};
GN Name=hisS-1 {ECO:0000255|HAMAP-Rule:MF_00127};
GN OrderedLocusNames=BA_3376, GBAA_3376, BAS3130;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00127};
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00127}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00127}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000255|HAMAP-Rule:MF_00127}.
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DR EMBL; AE016879; AAP27148.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT32484.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT55438.1; -; Genomic_DNA.
DR RefSeq; NP_845662.1; NC_003997.3.
DR RefSeq; WP_000405915.1; NZ_WXXJ01000007.1.
DR RefSeq; YP_029387.1; NC_005945.1.
DR AlphaFoldDB; Q81N41; -.
DR SMR; Q81N41; -.
DR STRING; 260799.BAS3130; -.
DR DNASU; 1084846; -.
DR EnsemblBacteria; AAP27148; AAP27148; BA_3376.
DR EnsemblBacteria; AAT32484; AAT32484; GBAA_3376.
DR GeneID; 45023132; -.
DR KEGG; ban:BA_3376; -.
DR KEGG; bar:GBAA_3376; -.
DR KEGG; bat:BAS3130; -.
DR PATRIC; fig|198094.11.peg.3351; -.
DR eggNOG; COG0124; Bacteria.
DR HOGENOM; CLU_025113_3_0_9; -.
DR OMA; YQIQKVW; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00773; HisRS-like_core; 1.
DR CDD; cd00859; HisRS_anticodon; 1.
DR Gene3D; 3.30.930.10; -; 1.
DR Gene3D; 3.40.50.800; -; 1.
DR HAMAP; MF_00127; His_tRNA_synth; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004154; Anticodon-bd.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR015807; His-tRNA-ligase.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR InterPro; IPR033656; HisRS_anticodon.
DR Pfam; PF03129; HGTP_anticodon; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; SSF55681; 1.
DR TIGRFAMs; TIGR00442; hisS; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT CHAIN 1..425
FT /note="Histidine--tRNA ligase 1"
FT /id="PRO_0000136093"
SQ SEQUENCE 425 AA; 47820 MW; AD68F3564B0E523D CRC64;
MEIRNVKGTK DYLPEEQVLR SKIKRACEDT FERYGCKPLE TPTLNMYELM SYKYGGGDEI
LKEIYTLQDQ GKRDLALRYD LTIPFAKVVA MNPNIRLPFK RYEIGKVFRD GPIKQGRFRE
FIQCDVDIVG VESVMAEAEL MSMAFELFQT LNLEVTIQYN NRKLLNGILQ AINIPTELTS
DVILSLDKIE KIGIDGVRKD VLERGISEEM ADTICNTVLS CLQLSIADFK EAFNNPLVAD
GVNELQQLQQ YLIALGINEN TIFNPFLARG LTMYTGTVYE IFLKDGSITS SIGSGGRYDN
IIGAFRGDDM SYPTVGISFG LDVIYTALSQ KETISSTADV FIIPLGTELQ CLQIAQQLRS
TTSLKIELEL AGRKLKRALN YANKENIPYV LIIGEEEICT ETVMLRNMKE GSEVKVPLSS
LSNYL
