ID   SYHC_ANTLO              Reviewed;         445 AA.
AC   Q6E6B4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Probable histidine--tRNA ligase, cytoplasmic;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
OS   Antonospora locustae (Microsporidian parasite) (Nosema locustae).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Antonospora.
OX   NCBI_TaxID=278021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15186746; DOI=10.1016/j.cub.2004.04.041;
RA   Slamovits C.H., Fast N.M., Law J.S., Keeling P.J.;
RT   "Genome compaction and stability in microsporidian intracellular
RT   parasites.";
RL   Curr. Biol. 14:891-896(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; AY548908; AAT12372.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6E6B4; -.
DR   SMR; Q6E6B4; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..445
FT                   /note="Probable histidine--tRNA ligase, cytoplasmic"
FT                   /id="PRO_0000388402"
SQ   SEQUENCE   445 AA;  49945 MW;  697C092D3497C007 CRC64;
     MDLRTPKGTH DYGPRECYLL NRFLRAVTEV FETHGAACID TPTFELRELL CNKYGDESRL
     IFDLADQGGD ICSLRYDLTV SFARFLAKHR VQRLKRFQIG KVFRRDQPSV SKGRLREFVQ
     CDLDIAGAYM EMVADAEAIC IMSECLDRVG HRYQIRISSR KILNALMEHS GIGRNNFATV
     CSTIDKMDRL PWADIAAELR TKGLVDGQVA VLKRYVCVSG GIEVIDTLRS GELYLYSDGK
     KGIDDLALLF KYLGIYGVGD RAVVDLSLAR GLDYYTGVIF EAALVDFKDV GSVAGGGRYD
     NLVSSVLGKK SEWSVPCVGF SLGVTRILSV MLKVDRRRTT ETEVFVGSSG GLLLEERMGV
     LSRLWRAGVA AETFYTRKYG YASLMEHVRK TDIPFFLLVG EKEIAENRFR LMYGEDRALQ
     MYGDIDTIVN FIKSHRAGQR PPAGL