ID   SYHC_NOSCE              Reviewed;         430 AA.
AC   C4V9J0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Probable histidine--tRNA ligase, cytoplasmic;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
GN   ORFNames=NCER_101238;
OS   Nosema ceranae (strain BRL01) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX   NCBI_TaxID=578460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01;
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; ACOL01000114; EEQ82106.1; -; Genomic_DNA.
DR   RefSeq; XP_002995777.1; XM_002995731.1.
DR   AlphaFoldDB; C4V9J0; -.
DR   SMR; C4V9J0; -.
DR   STRING; 578460.C4V9J0; -.
DR   EnsemblFungi; EEQ82106; EEQ82106; NCER_101238.
DR   KEGG; nce:NCER_101238; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_101238; -.
DR   HOGENOM; CLU_025113_4_2_1; -.
DR   InParanoid; C4V9J0; -.
DR   OMA; YQIQKVW; -.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..430
FT                   /note="Probable histidine--tRNA ligase, cytoplasmic"
FT                   /id="PRO_0000388404"
SQ   SEQUENCE   430 AA;  49035 MW;  20046E4E3A6A58BA CRC64;
     MSLKTPKGTT DLNPDDALVY EDLIDRTKNI FKLHGAVPID TPVFELKSIL LNKYGEDTKL
     IYDLKNNGGE ECALRYDLTV PFSRYMSMNK LKKIKRYQIG KVYRRDQPSV VQGRWREFLQ
     ADFDIAGESL PMMADSELVC CMNRLLKTYN IGDFVIRVSD KRILYGIFEV CEIPNNLFAT
     VSSSIDKLDK IAVNDINKEL KLKGLTDKQI INLNIYIQKS GTVDVLDFLR ENDVYKKCSE
     AVDDLCKLYE YCKIMKCSDH LIIDLSLARG LDYYTGMIIE GKYLNKNIGS VAGGGRYDNL
     IGSLENSSYT NTYNVPCAGF SIGLSRIFSC IQKPKVNTNV KVFISASGKL LLEERLKIQS
     ILWEANISLE TFYNKRNNPG EHKKYCVKHG IKYLIVVKEE QYNKGFVTVI EVNTNLENVI
     MIDNLPSHLQ