ID   SYH_AERPE               Reviewed;         435 AA.
AC   Q9YEB2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Histidine--tRNA ligase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
GN   Name=hisS; OrderedLocusNames=APE_0662.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; BA000002; BAA79634.2; -; Genomic_DNA.
DR   PIR; B72654; B72654.
DR   AlphaFoldDB; Q9YEB2; -.
DR   SMR; Q9YEB2; -.
DR   STRING; 272557.APE_0662.1; -.
DR   PRIDE; Q9YEB2; -.
DR   EnsemblBacteria; BAA79634; BAA79634; APE_0662.1.
DR   KEGG; ape:APE_0662.1; -.
DR   PATRIC; fig|272557.25.peg.475; -.
DR   eggNOG; arCOG00404; Archaea.
DR   BRENDA; 6.1.1.21; 171.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..435
FT                   /note="Histidine--tRNA ligase"
FT                   /id="PRO_0000136307"
SQ   SEQUENCE   435 AA;  48787 MW;  310F0CD86CACA9C7 CRC64;
     MAGGRPRPPR GFRDFPPEVM ILRKRLLSRL ERVFESYGFD PLDTPAVEYW ETLSGKYGEE
     AESRLIWRFQ DPWSGRWYAL RYDLTVPLAR FVASNPGLPM PFKRYHIGKV WRHEEPQKGR
     YREFVQCDAD IVGSPYPEAD AEIVSLAVDS IDALGLPGFR VRVNDRRLLA GVFEEELGFD
     NPLPIYRAID KLDKIGVEGV RRELERLGLP GSTVERIMEI ISWRGRPGEV LESVRRGYGS
     NEKVREALDH LEEMLSLADD KRVELDMSLV RGLDYYTGPI LEVVLDEPRI GSVAGGGRYD
     GLVGMFAGRD IPATGVSIGI ERIIDAGLEL GVYSLDVKTV AQVAVVVLDR RYYRYAWEAA
     RILRRGGLNV RIDLSRASGQ VQRRKASRLG IPVLAFVGAK EAEGGFLTLY SAAKGERVAV
     PLGEAVKAVE RLLPS