ID   SYH_BRADU               Reviewed;         506 AA.
AC   Q89DI2;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Histidine--tRNA ligase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
GN   Name=hisS; OrderedLocusNames=bll7457;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; BA000040; BAC52722.1; -; Genomic_DNA.
DR   RefSeq; NP_774097.1; NC_004463.1.
DR   RefSeq; WP_011090191.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89DI2; -.
DR   SMR; Q89DI2; -.
DR   STRING; 224911.27355740; -.
DR   EnsemblBacteria; BAC52722; BAC52722; BAC52722.
DR   GeneID; 64027214; -.
DR   KEGG; bja:bll7457; -.
DR   PATRIC; fig|224911.44.peg.7555; -.
DR   eggNOG; COG0124; Bacteria.
DR   HOGENOM; CLU_025113_3_2_5; -.
DR   InParanoid; Q89DI2; -.
DR   OMA; CDFDFIG; -.
DR   PhylomeDB; Q89DI2; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..506
FT                   /note="Histidine--tRNA ligase"
FT                   /id="PRO_0000136122"
SQ   SEQUENCE   506 AA;  55652 MW;  96674FE269866C5E CRC64;
     MAEKPKKPQK LKARLPRGLE DRDPAAIRAT REMVEKIRAV YELYGFEPVE TPAMEYTDAL
     GKFLPDQDRP NEGVFSFQDD DEQWISLRYD LTAPLARYVG ERYGTDGLVL PYRSYRVGYV
     FRNEKPGPGR FRQFMQFDAD TVGSATPAAD AEICMMAADT MEALGVQRGQ YVVKVNNRKV
     LDGVLEAIGL AGDENAARRL TVLRAIDKLD KFPADEVRKL LGPGRWDGGE EGKGDFTKGA
     NLSAAEADVV LAITKPRDDW KEAIAAAEAY LAKSEVGQAG VSELEEIAKL VMASGYGADR
     IKIDPSVVRG LEYYTGPVYE VELLLDTKDE KGRPVRFGSV GGGGRYDGLV SRFRGEPVPA
     TGFSIGVSRL QAALTLLGKL DTRPEFGPVV VTVFDRDRVA DYQKMVASLR TAGIRAELYL
     GNPKNMGNQL KYADRRNSPC VIIQGSDEKA RGELQIKDLI EGAKAAAAIA SNQEWRESRP
     AQFSCAEADL VAKVREVLAR HDVSWG