SYH_CHLPN
ID SYH_CHLPN Reviewed; 430 AA.
AC Q9Z7P1; Q9JQL3; Q9JSC4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Histidine--tRNA ligase;
DE EC=6.1.1.21;
DE AltName: Full=Histidyl-tRNA synthetase;
DE Short=HisRS;
GN Name=hisS; OrderedLocusNames=CPn_0663, CP_0084, CPj0663, CpB0689;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000305}.
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DR EMBL; AE001363; AAD18802.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF37970.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98870.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98618.1; -; Genomic_DNA.
DR PIR; D86573; D86573.
DR PIR; H72052; H72052.
DR RefSeq; NP_224859.1; NC_000922.1.
DR RefSeq; WP_010883301.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z7P1; -.
DR SMR; Q9Z7P1; -.
DR STRING; 115711.CP_0084; -.
DR EnsemblBacteria; AAD18802; AAD18802; CPn_0663.
DR EnsemblBacteria; AAF37970; AAF37970; CP_0084.
DR GeneID; 45050714; -.
DR KEGG; cpa:CP_0084; -.
DR KEGG; cpj:hisS; -.
DR KEGG; cpn:CPn_0663; -.
DR KEGG; cpt:CpB0689; -.
DR PATRIC; fig|115713.3.peg.733; -.
DR eggNOG; COG0124; Bacteria.
DR HOGENOM; CLU_025113_1_1_0; -.
DR OrthoDB; 277998at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00773; HisRS-like_core; 1.
DR Gene3D; 3.30.930.10; -; 1.
DR Gene3D; 3.40.50.800; -; 1.
DR HAMAP; MF_00127; His_tRNA_synth; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004154; Anticodon-bd.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR015807; His-tRNA-ligase.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR PANTHER; PTHR43707; PTHR43707; 1.
DR Pfam; PF03129; HGTP_anticodon; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; SSF55681; 1.
DR TIGRFAMs; TIGR00442; hisS; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis.
FT CHAIN 1..430
FT /note="Histidine--tRNA ligase"
FT /id="PRO_0000136135"
FT CONFLICT 76
FT /note="F -> V (in Ref. 3; BAA98870)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="G -> R (in Ref. 3; BAA98870)"
FT /evidence="ECO:0000305"
FT CONFLICT 96..97
FT /note="RS -> SA (in Ref. 3; BAA98870)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="N -> I (in Ref. 3; BAA98870)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 430 AA; 49551 MW; 1892BB7E7CAC9B74 CRC64;
MTVTLPKGVF DIFPYLADAK QLWRHTSLWH SVEKAIHTVC MLYGFCEIRT PIFEKSEVFL
HVGEESDVVK KEVYSFLDRK GRSMTLRPEG TAAVVRSFLE HGASHRSDNK FYYILPMFRY
ERQQAGRYRQ HHQFGVEAIG VRHPLRDAEV LALLWDFYSR VGLQHMQIQL NFLGGSETRF
RYDKVLRAYL KESMGELSAL SQQRFSTNVL RILDSKEPED QEIIRQAPPI LDYVSDEDLK
YFNEILDALR VLEIPYAINP RLVRGLDYYS DLVFEATTTF QEVSYALGGG GRYDGLISAF
GGASLPACGF GVGLERAIQT LLAQKRIEPQ FPHKLRLIPM EPDADQFCLE WSQHLRRLGI
PTEVDWSHKK VKGALKAAST EQVSFVCLIG ERELISQQLV IKNMSLRKEF FGTKEEVEQR
LLYEIQNTPL
