ID   SYH_CHLTR               Reviewed;         428 AA.
AC   O84547;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Histidine--tRNA ligase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
GN   Name=hisS; OrderedLocusNames=CT_543;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; AE001273; AAC68145.1; -; Genomic_DNA.
DR   PIR; H71500; H71500.
DR   RefSeq; NP_220058.1; NC_000117.1.
DR   RefSeq; WP_009871907.1; NC_000117.1.
DR   AlphaFoldDB; O84547; -.
DR   SMR; O84547; -.
DR   STRING; 813.O172_02985; -.
DR   EnsemblBacteria; AAC68145; AAC68145; CT_543.
DR   GeneID; 884320; -.
DR   KEGG; ctr:CT_543; -.
DR   PATRIC; fig|272561.5.peg.588; -.
DR   HOGENOM; CLU_025113_1_1_0; -.
DR   InParanoid; O84547; -.
DR   OMA; CDFDFIG; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..428
FT                   /note="Histidine--tRNA ligase"
FT                   /id="PRO_0000136136"
SQ   SEQUENCE   428 AA;  49189 MW;  9B9F59A096B8D958 CRC64;
     MSNALPKGVF DIFPYVTSPK NLWRNSSLWK RVEHAAHRIC NLYGFDEIRT PVFEKTETFL
     RVGEYSDIVK KEVYTFLDKK RRSLTLRPEG TAAVVRALLD HSADMRKDNK FYYILPMFRY
     ERQQSGRYRQ HHQFGLEAIG VRHPLRDAEV LSLLWDFYAA VGLQHMQIHV NFLGGQKTRA
     RYDEALREFF RKDLDRLSPL SQERYHANLL RILDSKEPED QEFIEKAPSI LDYIDDRDLS
     YFDAVLAQLK ALGISFAINP RLVRGLDYYT DLVFEAVTVV GEHSYALGGG GRYDELVAQS
     GGPSMPAFGF GVGLERVIQT LLEQGNSLST STRRLRLIPM DEQADAFCFS WANRLRNLGI
     ATEVDWSHKK PKLSLKDAAD QQVSFVCLLG EQELATKQFI VKDMSLHQSF SGAQQDVEQR
     LVYEVQNA