ID   SYH_HALSA               Reviewed;         432 AA.
AC   Q9HNP5;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Histidine--tRNA ligase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
GN   Name=hisS; OrderedLocusNames=VNG_2005G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; AE004437; AAG20175.1; -; Genomic_DNA.
DR   PIR; C84351; C84351.
DR   RefSeq; WP_010903476.1; NC_002607.1.
DR   AlphaFoldDB; Q9HNP5; -.
DR   SMR; Q9HNP5; -.
DR   STRING; 64091.VNG_2005G; -.
DR   PaxDb; Q9HNP5; -.
DR   EnsemblBacteria; AAG20175; AAG20175; VNG_2005G.
DR   GeneID; 5954438; -.
DR   GeneID; 62887333; -.
DR   KEGG; hal:VNG_2005G; -.
DR   PATRIC; fig|64091.14.peg.1532; -.
DR   HOGENOM; CLU_025113_3_1_2; -.
DR   InParanoid; Q9HNP5; -.
DR   OMA; CDFDFIG; -.
DR   OrthoDB; 47919at2157; -.
DR   PhylomeDB; Q9HNP5; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   CDD; cd00859; HisRS_anticodon; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR033656; HisRS_anticodon.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..432
FT                   /note="Histidine--tRNA ligase"
FT                   /id="PRO_0000136310"
SQ   SEQUENCE   432 AA;  46831 MW;  F81DB5770C00A187 CRC64;
     MYDRLKGFRD FYPAEMGPRR AAIDAIEDAA ASYGFREVGT PAMERTEMYV DKSGAEIVDE
     LYSFTDQGGR DVALTPELTP TVARMVVAKQ QALSKPIKWY SSRPFWRYEE PQQGRFREFY
     QTNLDIFGTS DPRADAEVLA VAADGLTSLG LTGADFEFRV SHRDILGGLL AAFDATVDTE
     AAIRTVDKRE KIERAAYLDD LAAAGLSYDQ AEQFDDLLDG DDLDALVSFA GTDRVRDAVA
     NLRNVLDAAE TLGVRQYCDV SLTTARGLDY YTGVVFECFD STGDVGRAVF GGGRYDDLIE
     RFGGQPTPAV GVAPGHATLN LLLENAGVLP DDEFTPDYYV LQVGDTDAEA ADVASALRER
     GNRVDTDITG RSFGAQMNYA DNVGADTVVI VGEQDLADGN VTIKNMASGE QTTAPIAAFP
     GAHDAPRVED FA