ID   SYH_KORCO               Reviewed;         428 AA.
AC   B1L6B4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Histidine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00127};
DE            EC=6.1.1.21 {ECO:0000255|HAMAP-Rule:MF_00127};
DE   AltName: Full=Histidyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00127};
DE            Short=HisRS {ECO:0000255|HAMAP-Rule:MF_00127};
GN   Name=hisS {ECO:0000255|HAMAP-Rule:MF_00127}; OrderedLocusNames=Kcr_1247;
OS   Korarchaeum cryptofilum (strain OPF8).
OC   Archaea; Candidatus Korarchaeota; Candidatus Korarchaeum.
OX   NCBI_TaxID=374847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OPF8;
RX   PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA   Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA   Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA   Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA   Richardson P., Keller M., Stetter K.O.;
RT   "A korarchaeal genome reveals new insights into the evolution of the
RT   Archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00127};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00127}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00127}.
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DR   EMBL; CP000968; ACB07993.1; -; Genomic_DNA.
DR   RefSeq; WP_012309890.1; NC_010482.1.
DR   AlphaFoldDB; B1L6B4; -.
DR   SMR; B1L6B4; -.
DR   STRING; 374847.Kcr_1247; -.
DR   EnsemblBacteria; ACB07993; ACB07993; Kcr_1247.
DR   GeneID; 6094524; -.
DR   KEGG; kcr:Kcr_1247; -.
DR   eggNOG; arCOG00404; Archaea.
DR   HOGENOM; CLU_025113_3_0_2; -.
DR   InParanoid; B1L6B4; -.
DR   OMA; CDFDFIG; -.
DR   OrthoDB; 47919at2157; -.
DR   PhylomeDB; B1L6B4; -.
DR   Proteomes; UP000001686; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..428
FT                   /note="Histidine--tRNA ligase"
FT                   /id="PRO_1000095564"
SQ   SEQUENCE   428 AA;  49382 MW;  67208B34A3CB4C1D CRC64;
     MVSIPRGFRD FPPPMMILRK RVLSKIEEIF RRYGFDPIET PSLEYWETVK GKLGEEAENK
     LMFIFPDFFS KEWYTLRYEL TFPLARYVAM HPETPLPFKR YHIGNVWRHE EPQKGRYREF
     LQCDADIVGS PYPEADAEVI SVNIDAMKSF DFENFRVRLN DRRLLTGVFE EELGINNPFP
     IYRAIDKLDK IGVDGVKGEL ARLGAHESLI GRIMELISTR GSFNEISNTF RRIENDKVKV
     ALDHLEEIFS IVSDDRLVFD LSLVRGLDYY TGPVFETSVS EPRIGSLAGG GRYDRLIGLY
     SGKDVPATGV SLGVERLIDA GLELGIFDLS ERSYTDVFIV SVRRENWRYA WRISRILRER
     GFSTSLDLMR RSQSAQREYA NKIGAKVIAF VGPSEEETET VTLYSRDLRK TVKISELIDS
     LREFLSVS