ID   BLAA_PROVU              Reviewed;         292 AA.
AC   P52660;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=HTH-type transcriptional regulator BlaA;
DE   AltName: Full=Beta-lactamase regulatory protein BlaA;
GN   Name=blaA; Synonyms=cumR;
OS   Proteus vulgaris.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=585;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B317;
RX   PubMed=7957242; DOI=10.1111/j.1432-1033.1994.tb20036.x;
RA   Datz M., Joris B., Azab E.A., Galleni M., van Beeumen J., Frere J.-M.,
RA   Martin H.H.;
RT   "A common system controls the induction of very different genes. The class-
RT   A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-
RT   lactamase.";
RL   Eur. J. Biochem. 226:149-157(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=5E78-1;
RA   Okuguchi M., Komai T., Makajima N., Eguchi H., Kuboki A., Ito T.,
RA   Meguro M., Nakata T., Sugimoto K.;
RL   Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positive regulator of the expression of the gene (blaB) for
CC       beta-lactamase.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X80128; CAA56428.1; -; Genomic_DNA.
DR   EMBL; D37831; BAA07083.1; -; Genomic_DNA.
DR   PIR; S51045; S51045.
DR   AlphaFoldDB; P52660; -.
DR   SMR; P52660; -.
DR   STRING; 585.DR95_684; -.
DR   eggNOG; COG0583; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08487; PBP2_BlaA; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037422; BlaA_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..292
FT                   /note="HTH-type transcriptional regulator BlaA"
FT                   /id="PRO_0000105595"
FT   DOMAIN          5..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   VARIANT         124
FT                   /note="L -> V (in strain: 5E78-1)"
FT   VARIANT         171
FT                   /note="D -> G (in strain: 5E78-1)"
FT   VARIANT         175
FT                   /note="P -> R (in strain: 5E78-1)"
FT   VARIANT         186
FT                   /note="T -> N (in strain: 5E78-1)"
FT   VARIANT         217
FT                   /note="P -> S (in strain: 5E78-1)"
FT   VARIANT         258
FT                   /note="L -> M (in strain: 5E78-1)"
FT   VARIANT         284
FT                   /note="N -> S (in strain: 5E78-1)"
FT   VARIANT         290
FT                   /note="I -> C (in strain: 5E78-1)"
SQ   SEQUENCE   292 AA;  33443 MW;  D07D3D9F7D4F3207 CRC64;
     MRTHLPLNAL RAFEASARHL NFTKAALELY VTQGAVSQQV RMLEERLGVI LFKRLPRGLE
     MTDDAQILFS VLTTAFSDIE RVFKQFERGE YRDVVSIAAV GTFAVGWLLP RLAEFRQLYP
     RIELNLRTNN NVVNLATEGL DFAIRFGEGL WPLTHNKALF SAPLTVLCSS DTAKPLQHPT
     DLINETLYRS YREDEWLQWF EKANMSPIKI TGSIFDPSRL MIESAIYEGG VALAPAKMFS
     REIENGQLVQ PFKIEVELGK YWLTYLKSKP MTASMEIFQQ WLMNEALKEI SE