ID   BLAA_STRCI              Reviewed;         326 AA.
AC   P33651;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional regulator BlaA;
DE   AltName: Full=Beta-lactamase regulatory protein BlaA;
GN   Name=blaA;
OS   Streptomyces cacaoi.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1898;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 3082 / DSM 40057 / JCM 4352 / KCC S-0352 / NBRC 12748 / NCIMB
RC   9626 / IMRU 3082;
RX   PubMed=1569015; DOI=10.1128/jb.174.9.2834-2842.1992;
RA   Urabe H., Ogawara H.;
RT   "Nucleotide sequence and transcriptional analysis of activator-regulator
RT   proteins for beta-lactamase in Streptomyces cacaoi.";
RL   J. Bacteriol. 174:2834-2842(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1435729; DOI=10.1007/bf00286179;
RA   Lenzini V.M., Magdalena J., Fraipont C., Joris B., Matagne A., Dusart J.;
RT   "Induction of a Streptomyces cacaoi beta-lactamase gene cloned in S.
RT   lividans.";
RL   Mol. Gen. Genet. 235:41-48(1992).
CC   -!- FUNCTION: Positive regulator of the expression of the gene (blaB) for
CC       beta-lactamase. It binds to the blaL-blaA intercistronic region.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; D00937; BAA00773.1; -; Genomic_DNA.
DR   EMBL; X63780; CAA45314.1; -; Genomic_DNA.
DR   PIR; A41855; A41855.
DR   AlphaFoldDB; P33651; -.
DR   SMR; P33651; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..326
FT                   /note="HTH-type transcriptional regulator BlaA"
FT                   /id="PRO_0000105596"
FT   DOMAIN          1..59
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   REGION          289..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  34756 MW;  3A5A6319DB7CA88D CRC64;
     MDVVNACRAF VKVSERGSFT VGAAAAQMSQ SVASRRVAAL EKHFGERLFD RASRRPSLTP
     FGRDMLPAAR RLVRVADVLE DEARAARSRP MRLAVPASCT TAELARLVAD SRERDIRLDV
     RTAGPEQRAE LVRTQEVRAG LLAVPPDQAL WAVPLGLAGA DEPQTRRVFV ESLRLRRGEP
     GPARCIRVQP EDDVPHIQGR LARLRDAVGL RPAQLSVAPD LTSATADVLS SDDLLLCSPA
     QAAELGLYWR PVGELRLARG YVLDAAVEAD AERLRGRLAP YLARALGATA DHGPDPATGA
     GPGADAGTEP GARAEPGAPE EGAQAC