ID   BLAB_STRCI              Reviewed;         312 AA.
AC   P33652;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Beta-lactamase regulatory protein BlaB;
GN   Name=blaB;
OS   Streptomyces cacaoi.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1898;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 3082 / DSM 40057 / JCM 4352 / KCC S-0352 / NBRC 12748 / NCIMB
RC   9626 / IMRU 3082;
RX   PubMed=1569015; DOI=10.1128/jb.174.9.2834-2842.1992;
RA   Urabe H., Ogawara H.;
RT   "Nucleotide sequence and transcriptional analysis of activator-regulator
RT   proteins for beta-lactamase in Streptomyces cacaoi.";
RL   J. Bacteriol. 174:2834-2842(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1435729; DOI=10.1007/bf00286179;
RA   Lenzini V.M., Magdalena J., Fraipont C., Joris B., Matagne A., Dusart J.;
RT   "Induction of a Streptomyces cacaoi beta-lactamase gene cloned in S.
RT   lividans.";
RL   Mol. Gen. Genet. 235:41-48(1992).
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DR   EMBL; D00937; BAA00774.1; -; Genomic_DNA.
DR   EMBL; X63780; CAA45315.1; -; Genomic_DNA.
DR   PIR; B41855; B41855.
DR   PDB; 2WUQ; X-ray; 1.80 A; A/B=2-312.
DR   PDBsum; 2WUQ; -.
DR   AlphaFoldDB; P33652; -.
DR   SMR; P33652; -.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR   GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR045155; Beta-lactam_cat.
DR   InterPro; IPR000871; Beta-lactam_class-A.
DR   PANTHER; PTHR35333; PTHR35333; 1.
DR   Pfam; PF13354; Beta-lactamase2; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Beta-lactamase regulatory protein BlaB"
FT                   /id="PRO_0000195468"
FT   CONFLICT        222
FT                   /note="E -> K (in Ref. 2; CAA45315)"
FT                   /evidence="ECO:0000305"
FT   HELIX           5..17
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          20..28
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   TURN            29..31
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          34..38
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           46..49
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           50..62
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          71..74
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           86..89
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          94..97
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           98..107
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           111..120
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           123..132
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           180..182
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   TURN            184..186
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           192..203
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           204..206
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           221..232
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          238..240
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           241..244
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          249..258
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          261..270
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   STRAND          275..286
FT                   /evidence="ECO:0007829|PDB:2WUQ"
FT   HELIX           292..312
FT                   /evidence="ECO:0007829|PDB:2WUQ"
SQ   SEQUENCE   312 AA;  33838 MW;  8E8CEB1322AD211B CRC64;
     MLNSESLLRE LRDALHEGGL TGSFLVRDLY TGEELGIDPD TELPTASLVK LPLALATLER
     IRLGEVDGAQ QIEVAPGRIT TPGPTGLSRF RHPARVAVDD LLYLSTSVSD GTASDALFEI
     TPPAQVEQMV REWGFRDLTV RHSMRELSET PAERFESADA HLAHALAISA GTSGRGHRVP
     QLDVARANTG TARAFVDLLE ALWAPVLTGP RPGRTSRALP PEPAARLREL MAANLLRHRL
     APDFASDAAT WSSKTGTLLN LRHEVGVVEH ADGQVFAVAV LTESQVPADS QPGAEALMAQ
     VARRLRDRLR EW