SYH_PYRAB
ID SYH_PYRAB Reviewed; 431 AA.
AC Q9UY31; G8ZK38;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Histidine--tRNA ligase;
DE EC=6.1.1.21;
DE AltName: Full=Histidyl-tRNA synthetase;
DE Short=HisRS;
GN Name=hisS; OrderedLocusNames=PYRAB16770; ORFNames=PAB1100;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000305}.
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DR EMBL; AJ248288; CAB50581.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE71145.1; -; Genomic_DNA.
DR PIR; G75017; G75017.
DR RefSeq; WP_010868795.1; NC_000868.1.
DR AlphaFoldDB; Q9UY31; -.
DR SMR; Q9UY31; -.
DR STRING; 272844.PAB1100; -.
DR EnsemblBacteria; CAB50581; CAB50581; PAB1100.
DR GeneID; 1495974; -.
DR KEGG; pab:PAB1100; -.
DR PATRIC; fig|272844.11.peg.1791; -.
DR eggNOG; arCOG00404; Archaea.
DR HOGENOM; CLU_025113_3_0_2; -.
DR OMA; CDFDFIG; -.
DR OrthoDB; 47919at2157; -.
DR PhylomeDB; Q9UY31; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:InterPro.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00773; HisRS-like_core; 1.
DR CDD; cd00859; HisRS_anticodon; 1.
DR Gene3D; 3.30.930.10; -; 1.
DR Gene3D; 3.40.50.800; -; 1.
DR HAMAP; MF_00127; His_tRNA_synth; 1.
DR HAMAP; MF_00125; HisZ; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004154; Anticodon-bd.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR015807; His-tRNA-ligase.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR InterPro; IPR033656; HisRS_anticodon.
DR InterPro; IPR004517; HisZ.
DR PANTHER; PTHR43707; PTHR43707; 1.
DR Pfam; PF03129; HGTP_anticodon; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; SSF55681; 1.
DR TIGRFAMs; TIGR00442; hisS; 1.
DR TIGRFAMs; TIGR00443; hisZ_biosyn_reg; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis.
FT CHAIN 1..431
FT /note="Histidine--tRNA ligase"
FT /id="PRO_0000136319"
SQ SEQUENCE 431 AA; 48877 MW; 04909CB03C0A05DC CRC64;
MIERVKGTRD FLPEEMVKRR WVFEKIREVF ETYGFKEVLT PVMEYTKLFQ LRSGEEVVKQ
LYAFKDKGGR DVALRPDMTS SVARLYVNSF QTAPKPIKWY YIANMFRYEE PQSGRYREFW
QAGVELIGSD KIEADAEVIA LFVDSYLSTG LKDFTVNIGD RVLLDEFAKM LGVKDDIGLM
RIIDKKDKLS QEEFLKALGE FGLDENGIEK VLNLIEIKGK PDDVLPLAEE LFTSERAKEE
ISRLYNLVDI LSWYEVDEWI QIDLGIARGF DYYTSIVFEA IVPNDLGIGS IGGGGRYDNL
IEVFGGKPTP ATGFAIGIER LIPILEWKGL LPELKAGPDV FVIPVGDSRD VATAIVTRLR
KAGIRSDIEL SGRKLRKALD YANRIGVRLS IIVGKRDLER GVVTIRDLES GNQVEVPVDN
VVTKVRELLN Q