BLAI_STAES
ID BLAI_STAES Reviewed; 126 AA.
AC P0A041; P18415;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Penicillinase repressor;
DE AltName: Full=Beta-lactamase repressor protein;
DE AltName: Full=Regulatory protein BlaI;
GN Name=blaI; Synonyms=penI; OrderedLocusNames=SE_p508;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OG Plasmid pSE-12228-05.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Transcriptional repressor that constitutively blocks
CC expression of beta-lactamase. Binds DNA as a dimer (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Upon exposure to beta-lactams, proteolytic cleavage at a single
CC site may impair dimerization and abolish repressor activity.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BlaI transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; AE015934; AAO06188.1; -; Genomic_DNA.
DR RefSeq; NP_863211.1; NC_005004.1.
DR RefSeq; WP_001284656.1; NZ_WBME01000048.1.
DR AlphaFoldDB; P0A041; -.
DR SMR; P0A041; -.
DR STRING; 176280.SE_1606; -.
DR EnsemblBacteria; AAO06188; AAO06188; SE_p508.
DR GeneID; 58063711; -.
DR KEGG; sep:SE_p508; -.
DR PATRIC; fig|176280.10.peg.2379; -.
DR eggNOG; COG3682; Bacteria.
DR HOGENOM; CLU_119090_2_1_9; -.
DR OMA; KWEKSTI; -.
DR PRO; PR:P0A041; -.
DR Proteomes; UP000001411; Plasmid pSE-12228-05.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005650; BlaI_family.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR34134; PTHR34134; 1.
DR Pfam; PF03965; Penicillinase_R; 1.
DR PIRSF; PIRSF019455; CopR_AtkY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cytoplasm; DNA-binding; Plasmid; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..126
FT /note="Penicillinase repressor"
FT /id="PRO_0000062794"
FT DNA_BIND 7..71
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 74..126
FT /note="Important for dimerization"
FT /evidence="ECO:0000250"
FT SITE 101..102
FT /note="Cleavage"
FT /evidence="ECO:0000250"
SQ SEQUENCE 126 AA; 14876 MW; E0759E83A5183117 CRC64;
MANKQVEISM AEWDVMNIIW GKKSVSANEI VVEIQKYKEV SDKTIRTLIT RLYKKEIIKR
YKSENIYFYS SNIKEDDIKM KTAKTFLNKL YGGDMKSLVL NFAKNEELNN KEIEELRDIL
NDISKK