ID   BLB2B_PHYIT             Reviewed;         100 AA.
AC   D0NZB7;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=RxLR effector protein PITG_18683 {ECO:0000303|PubMed:30984224};
DE   AltName: Full=Avrblb2-like effector PITG_18683 {ECO:0000303|PubMed:30984224};
DE   Flags: Precursor;
GN   ORFNames=PITG_18683;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   INTERACTION WITH HOST CALMODULIN, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=30984224; DOI=10.3389/fpls.2019.00374;
RA   Naveed Z.A., Bibi S., Ali G.S.;
RT   "The Phytophthora RXLR Effector Avrblb2 Modulates Plant Immunity by
RT   Interfering With Ca2+ Signaling Pathway.";
RL   Front. Plant Sci. 10:374-374(2019).
CC   -!- FUNCTION: Secreted effector that associates with calmodulin to
CC       interfere with plant defense-associated calcium signaling in hosts.
CC       {ECO:0000269|PubMed:30984224}.
CC   -!- SUBUNIT: Interacts with the host calmodulin.
CC       {ECO:0000269|PubMed:30984224}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30984224}. Host cell
CC       {ECO:0000269|PubMed:30984224}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:30984224}.
CC   -!- DOMAIN: The amino acids 78-82 in the C-terminal region of are important
CC       for binding to host calmodulin. {ECO:0000250|UniProtKB:D0P1A8}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028196; EEY68926.1; -; Genomic_DNA.
DR   RefSeq; XP_002997312.1; XM_002997266.1.
DR   AlphaFoldDB; D0NZB7; -.
DR   EnsemblProtists; PITG_18683T0; PITG_18683T0; PITG_18683.
DR   GeneID; 9477120; -.
DR   KEGG; pif:PITG_18683; -.
DR   VEuPathDB; FungiDB:PITG_18683; -.
DR   HOGENOM; CLU_158959_0_0_1; -.
DR   InParanoid; D0NZB7; -.
DR   OrthoDB; 1628005at2759; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..100
FT                   /note="RxLR effector protein PITG_18683"
FT                   /id="PRO_5003013735"
FT   MOTIF           43..57
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:30984224"
FT   MOTIF           78..82
FT                   /note="Calmodulin-binding motif"
FT                   /evidence="ECO:0000250|UniProtKB:D0P1A8"
SQ   SEQUENCE   100 AA;  10889 MW;  5E6650AEA7D9FDEC CRC64;
     MRSFLYGILA FAVLARSSAV AAFPIPDESR PLSKTSPDTV APRSLRVEAQ EVIQSGRGDG
     YGGFWKNIIP STNKIIKKPD IKIGKLIEAA KKAKKKMTKS