BLCAP_MOUSE
ID BLCAP_MOUSE Reviewed; 87 AA.
AC P62951; A2AFZ4; O60629; Q3TD76; Q5XJG3; Q9D3B5;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Bladder cancer-associated protein;
DE AltName: Full=Bladder cancer 10 kDa protein;
DE Short=Bc10;
GN Name=Blcap; Synonyms=Bc10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hahn Y., Chung J.H.;
RT "Murine homolog of human BC10 protein.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Aparicio S.A.J.R., John R.M., Surani A.M., Hawker K.;
RT "Structure of the murine imprinted locus for neuronatin reveals an unusual
RT organisation.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Embryonic brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May regulate cell proliferation and coordinate apoptosis and
CC cell cycle progression via a novel mechanism independent of both
CC p53/TP53 and NF-kappa-B. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BLCAP family. {ECO:0000305}.
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DR EMBL; AB037891; BAA90646.1; -; mRNA.
DR EMBL; AF303656; AAL01183.1; -; Genomic_DNA.
DR EMBL; AK011673; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK018127; BAB31083.1; -; mRNA.
DR EMBL; AK170338; BAE41728.1; -; mRNA.
DR EMBL; AL672259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026935; AAH26935.1; -; mRNA.
DR EMBL; BC083339; AAH83339.1; -; mRNA.
DR CCDS; CCDS16979.1; -.
DR RefSeq; NP_058612.3; NM_016916.3.
DR RefSeq; XP_006499963.1; XM_006499900.2.
DR AlphaFoldDB; P62951; -.
DR STRING; 10090.ENSMUSP00000105154; -.
DR PaxDb; P62951; -.
DR PRIDE; P62951; -.
DR Antibodypedia; 57254; 49 antibodies from 19 providers.
DR DNASU; 53619; -.
DR Ensembl; ENSMUST00000088494; ENSMUSP00000085849; ENSMUSG00000067787.
DR Ensembl; ENSMUST00000109528; ENSMUSP00000105154; ENSMUSG00000067787.
DR GeneID; 53619; -.
DR KEGG; mmu:53619; -.
DR UCSC; uc008npc.1; mouse.
DR CTD; 10904; -.
DR MGI; MGI:1858907; Blcap.
DR VEuPathDB; HostDB:ENSMUSG00000067787; -.
DR eggNOG; KOG4489; Eukaryota.
DR GeneTree; ENSGT00390000014105; -.
DR HOGENOM; CLU_181908_0_0_1; -.
DR InParanoid; P62951; -.
DR OMA; MERRPCY; -.
DR OrthoDB; 1521316at2759; -.
DR PhylomeDB; P62951; -.
DR TreeFam; TF313306; -.
DR BioGRID-ORCS; 53619; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Blcap; mouse.
DR PRO; PR:P62951; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P62951; protein.
DR Bgee; ENSMUSG00000067787; Expressed in embryonic brain and 258 other tissues.
DR ExpressionAtlas; P62951; baseline and differential.
DR Genevisible; P62951; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030262; P:apoptotic nuclear changes; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR009598; BC10.
DR PANTHER; PTHR13259; PTHR13259; 1.
DR SMART; SM01396; BC10; 1.
PE 3: Inferred from homology;
KW Apoptosis; Cell cycle; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..87
FT /note="Bladder cancer-associated protein"
FT /id="PRO_0000064851"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 2
FT /note="Y -> C (in Ref. 3; BAB31083 and 5; AAH83339)"
FT /evidence="ECO:0000305"
FT CONFLICT 5
FT /note="Q -> R (in Ref. 3; BAB31083)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="K -> R (in Ref. 3; BAB31083)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="T -> N (in Ref. 3; BAE41728)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 87 AA; 9876 MW; 06A45C03E27D3E87 CRC64;
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF LAALFLICYS
CWGNCFLYHC SDSPLPESAH DPGVVGT
