ID   BLE_GEOSE               Reviewed;         132 AA.
AC   P67925; P13014;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Bleomycin resistance protein;
DE            Short=BRP;
GN   Name=bleO;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OG   Plasmid pTB913, and Plasmid pTB19.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pTB913;
RX   PubMed=2677995; DOI=10.1093/nar/17.18.7283;
RA   van der Lelie D., Bron S., Venema G., Oskam L.;
RT   "Similarity of minus origins of replication and flanking open reading
RT   frames of plasmids pUB110, pTB913 and pMV158.";
RL   Nucleic Acids Res. 17:7283-7294(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pTB19;
RX   PubMed=1946749; DOI=10.1016/0147-619x(91)90034-t;
RA   Oskam L., Hillenga D.J., Venema G., Bron S.;
RT   "The large Bacillus plasmid pTB19 contains two integrated rolling-circle
RT   plasmids carrying mobilization functions.";
RL   Plasmid 26:30-39(1991).
CC   -!- FUNCTION: Binding protein with a strong affinity to the bleomycin
CC       family of antibiotics.
CC   -!- SIMILARITY: Belongs to the bleomycin resistance protein family.
CC       {ECO:0000305}.
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DR   EMBL; X15670; CAA33716.1; -; Genomic_DNA.
DR   EMBL; M63891; AAA98306.1; -; Genomic_DNA.
DR   PIR; S05986; S05986.
DR   RefSeq; WP_001621591.1; NC_025008.1.
DR   RefSeq; YP_009062839.1; NC_025008.1.
DR   AlphaFoldDB; P67925; -.
DR   SMR; P67925; -.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd08349; BLMA_like; 1.
DR   Gene3D; 3.10.180.10; -; 1.
DR   InterPro; IPR000335; Bleomycin-R.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PRINTS; PR00311; BLEOMYCINRST.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   PROSITE; PS51819; VOC; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Plasmid.
FT   CHAIN           1..132
FT                   /note="Bleomycin resistance protein"
FT                   /id="PRO_0000068560"
FT   DOMAIN          1..129
FT                   /note="VOC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
SQ   SEQUENCE   132 AA;  14922 MW;  2D7A1E2EF7187CBA CRC64;
     MLQSIPALPV GDIKKSIGFY CDKLGFTLVH HEDGFAVLMC NEVRIHLWEA SDEGWRSRSN
     DSPVCTGAES FIAGTASCRI EVEGIDELYQ HIKPLGILHP NTSLKDQWWD ERDFAVIDPD
     NNLISFFQQI KS