ID   BLE_STAAR               Reviewed;         132 AA.
AC   Q6GKR3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Bleomycin resistance protein;
DE            Short=BRP;
DE   AltName: Full=Bleomycin-binding protein;
GN   Name=ble; OrderedLocusNames=SAR0032;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Binding protein with a strong affinity to the bleomycin
CC       family of antibiotics, which confers resistance to these antibiotics by
CC       preventing the bleomycin-induced DNA breakage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bleomycin resistance protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG39061.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX571856; CAG39061.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q6GKR3; -.
DR   SMR; Q6GKR3; -.
DR   KEGG; sar:SAR0032; -.
DR   HOGENOM; CLU_046006_15_5_9; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd08349; BLMA_like; 1.
DR   Gene3D; 3.10.180.10; -; 1.
DR   InterPro; IPR000335; Bleomycin-R.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PRINTS; PR00311; BLEOMYCINRST.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   PROSITE; PS51819; VOC; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance.
FT   CHAIN           1..132
FT                   /note="Bleomycin resistance protein"
FT                   /id="PRO_0000300633"
FT   DOMAIN          1..129
FT                   /note="VOC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
SQ   SEQUENCE   132 AA;  14922 MW;  2D7A1E2EF7187CBA CRC64;
     MLQSIPALPV GDIKKSIGFY CDKLGFTLVH HEDGFAVLMC NEVRIHLWEA SDEGWRSRSN
     DSPVCTGAES FIAGTASCRI EVEGIDELYQ HIKPLGILHP NTSLKDQWWD ERDFAVIDPD
     NNLISFFQQI KS