SYJ2B_BOVIN
ID SYJ2B_BOVIN Reviewed; 145 AA.
AC Q3T0C9;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Synaptojanin-2-binding protein {ECO:0000250|UniProtKB:P57105, ECO:0000312|EMBL:AAI02452.1};
DE AltName: Full=Activin receptor-interacting protein 2 {ECO:0000250|UniProtKB:Q9D6K5};
DE AltName: Full=Mitochondrial outer membrane protein 25 {ECO:0000250|UniProtKB:P57105};
GN Name=SYNJ2BP {ECO:0000312|EMBL:AAI02452.1};
GN Synonyms=ARIP2 {ECO:0000250|UniProtKB:Q9D6K5},
GN OMP25 {ECO:0000250|UniProtKB:P57105};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:AAI02452.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI02452.1};
RC TISSUE=Ileum {ECO:0000312|EMBL:AAI02452.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates endocytosis of activin type 2 receptor kinases
CC through the Ral/RALBP1-dependent pathway and may be involved in
CC suppression of activin-induced signal transduction.
CC {ECO:0000250|UniProtKB:Q9D6K5}.
CC -!- SUBUNIT: Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the
CC unique motif in the C-terminus) (By similarity). Interacts (via C-
CC terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-
CC terminus) and ACVR2B (via C-terminus). Forms a ternary complex with
CC ACVR2A and RALBP1 (By similarity). Interacts with MAPK12 (By
CC similarity). Interacts with DLL1; enhances DLL1 protein stability, and
CC promotes notch signaling in endothelial cells (By similarity).
CC {ECO:0000250|UniProtKB:P57105, ECO:0000250|UniProtKB:Q9D6K5,
CC ECO:0000250|UniProtKB:Q9WVJ4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q9D6K5, ECO:0000250|UniProtKB:Q9WVJ4}; Single-
CC pass type IV membrane protein {ECO:0000250|UniProtKB:Q9D6K5,
CC ECO:0000250|UniProtKB:Q9WVJ4}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9D6K5, ECO:0000250|UniProtKB:Q9WVJ4}.
CC Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9D6K5,
CC ECO:0000250|UniProtKB:Q9WVJ4}.
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DR EMBL; BC102451; AAI02452.1; -; mRNA.
DR RefSeq; NP_001030432.1; NM_001035355.2.
DR AlphaFoldDB; Q3T0C9; -.
DR SMR; Q3T0C9; -.
DR STRING; 9913.ENSBTAP00000020908; -.
DR PaxDb; Q3T0C9; -.
DR PRIDE; Q3T0C9; -.
DR GeneID; 525107; -.
DR KEGG; bta:525107; -.
DR CTD; 55333; -.
DR eggNOG; KOG3528; Eukaryota.
DR InParanoid; Q3T0C9; -.
DR OrthoDB; 1502481at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:1903671; P:negative regulation of sprouting angiogenesis; ISS:UniProtKB.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR GO; GO:0097120; P:receptor localization to synapse; IBA:GO_Central.
DR GO; GO:0008593; P:regulation of Notch signaling pathway; ISS:UniProtKB.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endocytosis; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..145
FT /note="Synaptojanin-2-binding protein"
FT /id="PRO_0000375981"
FT TOPO_DOM 1..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..145
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 13..100
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ SEQUENCE 145 AA; 15810 MW; 606A3724DDF3F4BF CRC64;
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIFVSRIKEN GAAALDGRLQ
EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL QVQNGPIGPQ GEGEPSGIPI
AMVLVPVFAL TMVAAWAFMR YRQRL
