ID   BLG4_BLAGE              Reviewed;         182 AA.
AC   P54962;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Allergen Bla g 4;
DE   AltName: Full=Allergen Bla g IV;
DE   AltName: Allergen=Bla g 4;
DE   Flags: Precursor; Fragment;
OS   Blattella germanica (German cockroach) (Blatta germanica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae;
OC   Blattellinae; Blattella.
OX   NCBI_TaxID=6973;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=8537384; DOI=10.1074/jbc.270.52.31196;
RA   Arruda L.K., Vailes L.D., Hayden M.L., Benjamin D.C., Chapman M.D.;
RT   "Cloning of cockroach allergen, Bla g 4, identifies ligand binding proteins
RT   (or calycins) as a cause of IgE antibody responses.";
RL   J. Biol. Chem. 270:31196-31201(1995).
CC   -!- FUNCTION: Probable ligand-binding protein.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:8537384}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Triabin family.
CC       {ECO:0000305}.
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DR   EMBL; U40767; AAA87851.1; -; mRNA.
DR   PDB; 3EBK; X-ray; 1.90 A; A/B=7-182.
DR   PDBsum; 3EBK; -.
DR   AlphaFoldDB; P54962; -.
DR   SMR; P54962; -.
DR   Allergome; 143; Bla g 4.
DR   Allergome; 3141; Bla g 4.0101.
DR   EvolutionaryTrace; P54962; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030682; P:mitigation of host defenses by symbiont; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR005657; Triabi/Procalin.
DR   Pfam; PF03973; Triabin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Glycoprotein; Secreted; Signal.
FT   SIGNAL          <1..12
FT                   /evidence="ECO:0000255"
FT   CHAIN           13..182
FT                   /note="Allergen Bla g 4"
FT                   /id="PRO_0000017984"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   TURN            14..16
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   HELIX           28..31
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          33..41
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   HELIX           44..47
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          48..56
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   TURN            57..59
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          60..66
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          74..83
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          86..91
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   HELIX           96..98
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          100..107
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          109..117
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   HELIX           120..122
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          126..133
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   TURN            135..137
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   HELIX           148..169
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   HELIX           174..176
FT                   /evidence="ECO:0007829|PDB:3EBK"
FT   STRAND          177..179
FT                   /evidence="ECO:0007829|PDB:3EBK"
SQ   SEQUENCE   182 AA;  20927 MW;  54B5C17485BEDF89 CRC64;
     AVLALCATDT LANEDCFRHE SLVPNLDYER FRGSWIIAAG TSEALTQYKC WIDRFSYDDA
     LVSKYTDSQG KNRTTIRGRT KFEGNKFTID YNDKGKAFSA PYSVLATDYE NYAIVEGCPA
     AANGHVIYVQ IRFSVRRFHP KLGDKEMIQH YTLDQVNQHK KAIEEDLKHF NLKYEDLHST
     CH