BLH10_ARATH
ID BLH10_ARATH Reviewed; 538 AA.
AC Q9FXG8; Q3YIF0; Q3YIF5; Q3YIG1; Q3YIG2; Q3YIG4; Q3YIG6; Q940X8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=BEL1-like homeodomain protein 10;
DE Short=BEL1-like protein 10;
GN Name=BLH10; Synonyms=BLH5; OrderedLocusNames=At1g19700;
GN ORFNames=F14P1.20, F6F9.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Milich R., Putterill J.J.;
RT "The BELL family of homeodomain proteins in Arabidopsis.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-405 (ISOFORM 1), AND VARIANTS
RP SER-193; ASN-204; GLY-213-214-SER; ASN-218; ASP-233; HIS-236 AND CYS-289.
RC STRAIN=cv. Ag-0, cv. Bla-10, cv. Bs-1, cv. Chi-1, cv. Co-1, cv. Cvi-0,
RC cv. Da(1)-12, cv. Gr-3, cv. Ita-0, cv. Kas-1, cv. Kr-0,
RC cv. Landsberg erecta, cv. Lip-0, cv. Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0,
RC cv. Te-0, and cv. Tu-1;
RX PubMed=15911589; DOI=10.1534/genetics.104.036152;
RA Cork J.M., Purugganan M.D.;
RT "High-diversity genes in the Arabidopsis genome.";
RL Genetics 170:1897-1911(2005).
RN [6]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA Smith H.M.S., Campbell B.C.C., Hake S.;
RT "Competence to respond to floral inductive signals requires the homeobox
RT genes PENNYWISE and POUND-FOOLISH.";
RL Curr. Biol. 14:812-817(2004).
RN [7]
RP INTERACTION WITH OFP1; OFP2; OFP4 AND OFP5.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [8]
RP INTERACTION WITH TLP1.
RX PubMed=17982713; DOI=10.1007/s10265-007-0118-8;
RA Ogura Y., Komatsu A., Zikihara K., Nanjo T., Tokutomi S., Wada M.,
RA Kiyosue T.;
RT "Blue light diminishes interaction of PAS/LOV proteins, putative blue light
RT receptors in Arabidopsis thaliana, with their interacting partners.";
RL J. Plant Res. 121:97-105(2008).
CC -!- SUBUNIT: Interacts with TLP1. May form heterodimeric complexes with
CC TALE/KNOX proteins (By similarity). Interacts with OFP1, OFP2, OFP4 and
CC OFP5. {ECO:0000250, ECO:0000269|PubMed:15781858,
CC ECO:0000269|PubMed:17982713}.
CC -!- INTERACTION:
CC Q9FXG8; Q9LQT8: GAI; NbExp=3; IntAct=EBI-1153895, EBI-963606;
CC Q9FXG8; P46640: KNAT2; NbExp=4; IntAct=EBI-1153895, EBI-1153809;
CC Q9FXG8; P48002: KNAT5; NbExp=3; IntAct=EBI-1153895, EBI-1153922;
CC Q9FXG8; Q84JS6: KNAT6; NbExp=4; IntAct=EBI-1153895, EBI-530499;
CC Q9FXG8; Q9SLH3: RGA; NbExp=3; IntAct=EBI-1153895, EBI-963624;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=BLH10B;
CC IsoId=Q9FXG8-1; Sequence=Displayed;
CC Name=2; Synonyms=BLH10A;
CC IsoId=Q9FXG8-2; Sequence=VSP_030557, VSP_030558;
CC -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC between the TALE/BELL proteins and the TALE/KNOX proteins.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR EMBL; AY570508; AAS78200.1; -; mRNA.
DR EMBL; AC007797; AAG12557.1; -; Genomic_DNA.
DR EMBL; AC024609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE29884.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29885.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29886.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60244.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60245.1; -; Genomic_DNA.
DR EMBL; AY052366; AAK96557.1; -; mRNA.
DR EMBL; AY059666; AAL31159.1; -; mRNA.
DR EMBL; DQ132268; AAZ73632.1; -; Genomic_DNA.
DR EMBL; DQ132269; AAZ73633.1; -; Genomic_DNA.
DR EMBL; DQ132270; AAZ73634.1; -; Genomic_DNA.
DR EMBL; DQ132271; AAZ73635.1; -; Genomic_DNA.
DR EMBL; DQ132272; AAZ73636.1; -; Genomic_DNA.
DR EMBL; DQ132273; AAZ73637.1; -; Genomic_DNA.
DR EMBL; DQ132274; AAZ73638.1; -; Genomic_DNA.
DR EMBL; DQ132275; AAZ73639.1; -; Genomic_DNA.
DR EMBL; DQ132276; AAZ73640.1; -; Genomic_DNA.
DR EMBL; DQ132277; AAZ73641.1; -; Genomic_DNA.
DR EMBL; DQ132278; AAZ73642.1; -; Genomic_DNA.
DR EMBL; DQ132279; AAZ73643.1; -; Genomic_DNA.
DR EMBL; DQ132280; AAZ73644.1; -; Genomic_DNA.
DR EMBL; DQ132281; AAZ73645.1; -; Genomic_DNA.
DR EMBL; DQ132282; AAZ73646.1; -; Genomic_DNA.
DR EMBL; DQ132283; AAZ73647.1; -; Genomic_DNA.
DR EMBL; DQ132284; AAZ73648.1; -; Genomic_DNA.
DR EMBL; DQ132285; AAZ73649.1; -; Genomic_DNA.
DR EMBL; DQ132286; AAZ73650.1; -; Genomic_DNA.
DR PIR; H86329; H86329.
DR RefSeq; NP_001154352.1; NM_001160880.2. [Q9FXG8-1]
DR RefSeq; NP_001185040.1; NM_001198111.2. [Q9FXG8-1]
DR RefSeq; NP_001319044.1; NM_001332403.1. [Q9FXG8-1]
DR RefSeq; NP_001322544.1; NM_001332404.1. [Q9FXG8-1]
DR RefSeq; NP_173400.1; NM_101826.3. [Q9FXG8-1]
DR AlphaFoldDB; Q9FXG8; -.
DR SMR; Q9FXG8; -.
DR BioGRID; 23797; 21.
DR IntAct; Q9FXG8; 22.
DR STRING; 3702.AT1G19700.2; -.
DR iPTMnet; Q9FXG8; -.
DR PaxDb; Q9FXG8; -.
DR PRIDE; Q9FXG8; -.
DR ProteomicsDB; 240405; -. [Q9FXG8-1]
DR EnsemblPlants; AT1G19700.1; AT1G19700.1; AT1G19700. [Q9FXG8-1]
DR EnsemblPlants; AT1G19700.2; AT1G19700.2; AT1G19700. [Q9FXG8-1]
DR EnsemblPlants; AT1G19700.3; AT1G19700.3; AT1G19700. [Q9FXG8-1]
DR EnsemblPlants; AT1G19700.4; AT1G19700.4; AT1G19700. [Q9FXG8-1]
DR EnsemblPlants; AT1G19700.5; AT1G19700.5; AT1G19700. [Q9FXG8-1]
DR GeneID; 838558; -.
DR Gramene; AT1G19700.1; AT1G19700.1; AT1G19700. [Q9FXG8-1]
DR Gramene; AT1G19700.2; AT1G19700.2; AT1G19700. [Q9FXG8-1]
DR Gramene; AT1G19700.3; AT1G19700.3; AT1G19700. [Q9FXG8-1]
DR Gramene; AT1G19700.4; AT1G19700.4; AT1G19700. [Q9FXG8-1]
DR Gramene; AT1G19700.5; AT1G19700.5; AT1G19700. [Q9FXG8-1]
DR KEGG; ath:AT1G19700; -.
DR Araport; AT1G19700; -.
DR TAIR; locus:2013154; AT1G19700.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_011058_6_1_1; -.
DR InParanoid; Q9FXG8; -.
DR OMA; EPNSTNQ; -.
DR OrthoDB; 626500at2759; -.
DR PhylomeDB; Q9FXG8; -.
DR PRO; PR:Q9FXG8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FXG8; baseline and differential.
DR Genevisible; Q9FXG8; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR006563; POX_dom.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF07526; POX; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00574; POX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..538
FT /note="BEL1-like homeodomain protein 10"
FT /id="PRO_0000315466"
FT DNA_BIND 351..413
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 169..185
FT /note="SR/KY domain"
FT REGION 201..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..302
FT /note="BELL domain"
FT REGION 434..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 249..267
FT /note="VDKRYNQYYHQMEALASSF -> NLSPFSCSSRRNKGTNSDC (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_030557"
FT VAR_SEQ 268..538
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_030558"
FT VARIANT 193
FT /note="G -> S (in strain: cv. Ag-0, cv. Bs-1, cv. Chi-1,
FT cv. Cvi-0, cv. Kas-1, cv. Ita-0, cv. Landsberg erecta, cv.
FT Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0)"
FT /evidence="ECO:0000269|PubMed:15911589"
FT VARIANT 204
FT /note="S -> N (in strain: cv. Ag-0, cv. Bs-1, cv. Chi-1,
FT cv. Cvi-0, cv. Kas-1, cv. Ita-0, cv. Landsberg erecta, cv.
FT Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0)"
FT /evidence="ECO:0000269|PubMed:15911589"
FT VARIANT 213
FT /note="G -> GS (in strain: cv. Ag-0, cv. Bs-1, cv. Chi-1,
FT cv. Cvi-0, cv. Kas-1, cv. Ita-0, cv. Landsberg erecta, cv.
FT Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0)"
FT VARIANT 218
FT /note="S -> N (in strain: cv. Ag-0, cv. Bs-1, cv. Chi-1,
FT cv. Cvi-0, cv. Kas-1, cv. Ita-0, cv. Landsberg erecta, cv.
FT Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0)"
FT /evidence="ECO:0000269|PubMed:15911589"
FT VARIANT 233
FT /note="E -> D (in strain: cv. Ag-0, cv. Bs-1, cv. Chi-1,
FT cv. Cvi-0, cv. Kas-1, cv. Ita-0, cv. Landsberg erecta, cv.
FT Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0)"
FT /evidence="ECO:0000269|PubMed:15911589"
FT VARIANT 236
FT /note="Q -> H (in strain: cv. Ag-0, cv. Bs-1, cv. Chi-1,
FT cv. Cvi-0, cv. Kas-1, cv. Ita-0, cv. Landsberg erecta, cv.
FT Lisse, cv. Me-0, cv. Mt-0, cv. Oy-0)"
FT /evidence="ECO:0000269|PubMed:15911589"
FT VARIANT 289
FT /note="R -> C (in strain: cv. Ag-0, cv. Lisse)"
FT /evidence="ECO:0000269|PubMed:15911589"
SQ SEQUENCE 538 AA; 60636 MW; 444FE541B7FF6803 CRC64;
MAVYYTSNVG CYQQEPIFLN HQQQNQQASS SSAAASFTVT GGDTVRNEMV FIPPTTTGDV
VTGNGTVSSS DLSFHDGQGL SLSLGTQISV APFHFHQYQL GFTSQNPSIS VKETSPFHVD
EMSVKSKEMI LLGQSDPSSG YAGNGGNGFY NNYRYNETSG GFMSSVLRSR YLKPAQNLLD
EVVSVKKELN QMGKKKMKVN DFNSGSKEIE GGGGELSSDS NGKSIELSTI EREELQNKKN
KLLTMVDEVD KRYNQYYHQM EALASSFEIV AGLGSAKPYT SVALNRISRH FRALRDAIKE
QIQIVREKLG EKGGESLDEQ QGERIPRLRY LDQRLRQQRA LHQQLGMVRP AWRPQRGLPE
NSVSVLRAWL FEHFLHPYPK ESEKIMLAKQ TGLSKNQVAN WFINARVRLW KPMIEEMYKE
EFGDESELLI SKSSQEPNST NQEDSSSQQQ QQQENNNNSN LAYSSADTTN IVFSSETKPD
RVLGNDNDPQ QQQINRSSDY DTLMNYHGFG VDDYRYISGS NQQESRFSNS HHLHDFVV
