BLH1_ARATH
ID BLH1_ARATH Reviewed; 680 AA.
AC Q9SJ56; Q42302; Q94KL4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 155.
DE RecName: Full=BEL1-like homeodomain protein 1;
DE Short=BEL1-like protein 1;
DE AltName: Full=Protein EMBRYO SAC DEVELOPMENT ARREST 29;
GN Name=BLH1; Synonyms=EDA29; OrderedLocusNames=At2g35940; ORFNames=F11F19.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pidkowich M.S., Samach A., Modrusan Z., Haughn G.W.;
RT "A family of BEL1-like homeodomain (BLH) proteins in Arabidopsis
RT thaliana.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-459.
RC STRAIN=cv. Columbia;
RA Bardet C., Dabos P., Tremousaygue D., Lescure B.;
RT "The Arabidopsis thaliana transcribed genome: the GDR cDNA program.";
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA Smith H.M.S., Campbell B.C.C., Hake S.;
RT "Competence to respond to floral inductive signals requires the homeobox
RT genes PENNYWISE and POUND-FOOLISH.";
RL Curr. Biol. 14:812-817(2004).
RN [8]
RP INTERACTION WITH OFP1; OFP2; OFP3; OFP4; OFP5 AND OFP15.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [9]
RP INTERACTION WITH KNAT2 AND KNAT5.
RX PubMed=17873098; DOI=10.1105/tpc.106.048769;
RA Kumar R., Kushalappa K., Godt D., Pidkowich M.S., Pastorelli S.,
RA Hepworth S.R., Haughn G.W.;
RT "The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act
RT redundantly to regulate KNOX expression spatially in leaf margins.";
RL Plant Cell 19:2719-2735(2007).
CC -!- SUBUNIT: May form heterodimeric complexes with TALE/KNOX proteins KNAT2
CC and KNAT 5. Interacts with OFP1, OFP2, OFP3, OFP4, OFP5 and OFP15.
CC {ECO:0000269|PubMed:15781858, ECO:0000269|PubMed:17873098}.
CC -!- INTERACTION:
CC Q9SJ56; P46640: KNAT2; NbExp=3; IntAct=EBI-1148379, EBI-1153809;
CC Q9SJ56; Q84JS6: KNAT6; NbExp=3; IntAct=EBI-1148379, EBI-530499;
CC Q9SJ56; Q38874: STM; NbExp=3; IntAct=EBI-1148379, EBI-530523;
CC Q9SJ56; Q5CCK4: VAL2; NbExp=3; IntAct=EBI-1148379, EBI-15193683;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC between the TALE/BELL proteins and the TALE/KNOX proteins.
CC -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR EMBL; AF353094; AAK43836.1; -; mRNA.
DR EMBL; AC007017; AAD21463.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09179.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09180.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09181.1; -; Genomic_DNA.
DR EMBL; AY072175; AAL59997.1; -; mRNA.
DR EMBL; AY096548; AAM20198.1; -; mRNA.
DR EMBL; AY099854; AAM20705.1; -; mRNA.
DR EMBL; BT008422; AAP37781.1; -; mRNA.
DR EMBL; AK227272; BAE99297.1; -; mRNA.
DR EMBL; Z35398; CAA84582.1; -; mRNA.
DR PIR; H84774; H84774.
DR RefSeq; NP_001031490.1; NM_001036413.3.
DR RefSeq; NP_181138.1; NM_129153.3.
DR RefSeq; NP_850256.1; NM_179925.3.
DR AlphaFoldDB; Q9SJ56; -.
DR SMR; Q9SJ56; -.
DR BioGRID; 3511; 40.
DR IntAct; Q9SJ56; 44.
DR STRING; 3702.AT2G35940.3; -.
DR iPTMnet; Q9SJ56; -.
DR PaxDb; Q9SJ56; -.
DR PRIDE; Q9SJ56; -.
DR ProteomicsDB; 240354; -.
DR EnsemblPlants; AT2G35940.1; AT2G35940.1; AT2G35940.
DR EnsemblPlants; AT2G35940.2; AT2G35940.2; AT2G35940.
DR EnsemblPlants; AT2G35940.3; AT2G35940.3; AT2G35940.
DR GeneID; 818167; -.
DR Gramene; AT2G35940.1; AT2G35940.1; AT2G35940.
DR Gramene; AT2G35940.2; AT2G35940.2; AT2G35940.
DR Gramene; AT2G35940.3; AT2G35940.3; AT2G35940.
DR KEGG; ath:AT2G35940; -.
DR Araport; AT2G35940; -.
DR TAIR; locus:2039250; AT2G35940.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_011058_4_0_1; -.
DR InParanoid; Q9SJ56; -.
DR OMA; SGTHQNF; -.
DR OrthoDB; 772631at2759; -.
DR PhylomeDB; Q9SJ56; -.
DR PRO; PR:Q9SJ56; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJ56; baseline and differential.
DR Genevisible; Q9SJ56; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:TAIR.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010197; P:polar nucleus fusion; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR GO; GO:0010201; P:response to continuous far red light stimulus by the high-irradiance response system; IMP:TAIR.
DR GO; GO:0009610; P:response to symbiotic fungus; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR006563; POX_dom.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF07526; POX; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00574; POX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..680
FT /note="BEL1-like homeodomain protein 1"
FT /id="PRO_0000315457"
FT DNA_BIND 385..447
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 35..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..209
FT /note="SR/KY domain"
FT REGION 220..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..335
FT /note="BELL domain"
FT REGION 458..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 515
FT /note="S -> C (in Ref. 1; AAK43836)"
FT /evidence="ECO:0000305"
FT CONFLICT 610
FT /note="H -> D (in Ref. 1; AAK43836)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 680 AA; 74463 MW; 45C0E77996AB8737 CRC64;
MAAYFHGNPP EISAGSDGGL QTLILMNPTT YVQYTQQDND SNNNNNSNNS NNNNTNTNTN
NNNSSFVFLD SHAPQPNASQ QFVGIPLSGH EAASITAADN ISVLHGYPPR VQYSLYGSHQ
VDPTHQQAAC ETPRAQQGLS LTLSSQQQQQ QQHHQQHQPI HVGFGSGHGE DIRVGSGSTG
SGVTNGIANL VSSKYLKAAQ ELLDEVVNAD SDDMNAKSQL FSSKKGSCGN DKPVGESSAG
AGGEGSGGGA EAAGKRPVEL GTAERQEIQM KKAKLSNMLH EVEQRYRQYH QQMQMVISSF
EQAAGIGSAK SYTSLALKTI SRQFRCLKEA IAGQIKAANK SLGEEDSVSG VGRFEGSRLK
FVDHHLRQQR ALQQLGMIQH PSNNAWRPQR GLPERAVSVL RAWLFEHFLH PYPKDSDKHM
LAKQTGLTRS QVSNWFINAR VRLWKPMVEE MYMEEMKEQA KNMGSMEKTP LDQSNEDSAS
KSTSNQEKSP MADTNYHMNP NHNGDLEGVT GMQGSPKRLR TSDETMMQPI NADFSSNEKL
TMKILEERQG IRSDGGYPFM GNFGQYQMDE MSRFDVVSDQ ELMAQRYSGN NNGVSLTLGL
PHCDSLSSTH HQGFMQTHHG IPIGRRVKIG ETEEYGPATI NGGSSTTTAH SSAAAAAAYN
GMNIQNQKRY VAQLLPDFVA
