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BLH3_ARATH
ID   BLH3_ARATH              Reviewed;         524 AA.
AC   Q9FWS9; Q0WW07; Q8W4I2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=BEL1-like homeodomain protein 3;
DE            Short=BEL1-like protein 3;
GN   Name=BLH3; OrderedLocusNames=At1g75410; ORFNames=F1B16.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pidkowich M.S., Samach A., Modrusan Z., Haughn G.W.;
RT   "A family of BEL1-like homeodomain (BLH) proteins in Arabidopsis
RT   thaliana.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Milich R.J., Putterill J.J.;
RT   "The BELL family of homeodomain proteins in Arabidopsis.";
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-431.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   GENE FAMILY ORGANIZATION.
RX   PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA   Smith H.M.S., Campbell B.C.C., Hake S.;
RT   "Competence to respond to floral inductive signals requires the homeobox
RT   genes PENNYWISE and POUND-FOOLISH.";
RL   Curr. Biol. 14:812-817(2004).
RN   [9]
RP   INTERACTION WITH OFP1; OFP2; OFP3; OFP4; OFP5 AND OFP15.
RX   PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA   Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT   "A central role of Arabidopsis thaliana ovate family proteins in networking
RT   and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN   [10]
RP   FUNCTION, AND INTERACTION WITH STM.
RX   PubMed=16513846; DOI=10.1093/nar/gkl016;
RA   Cole M., Nolte C., Werr W.;
RT   "Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on
RT   heterodimerization with BLH proteins expressed in discrete sub-domains of
RT   the shoot apical meristem of Arabidopsis thaliana.";
RL   Nucleic Acids Res. 34:1281-1292(2006).
CC   -!- FUNCTION: Transcription factor that is responsive of the nuclear import
CC       of SHOOT MERISTEMLESS (STM). {ECO:0000269|PubMed:16513846}.
CC   -!- SUBUNIT: May form heterodimeric complex with the TALE/KNOX protein STM.
CC       Interacts with OFP1, OFP2, OFP3, OFP4, OFP5 and OFP15.
CC       {ECO:0000269|PubMed:15781858, ECO:0000269|PubMed:16513846}.
CC   -!- INTERACTION:
CC       Q9FWS9; P48000: KNAT3; NbExp=3; IntAct=EBI-912915, EBI-1153908;
CC       Q9FWS9; Q38874: STM; NbExp=4; IntAct=EBI-912915, EBI-530523;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC       between the TALE/BELL proteins and the TALE/KNOX proteins.
CC   -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR   EMBL; AF353093; AAK43835.1; -; mRNA.
DR   EMBL; AY598452; AAT09418.1; -; mRNA.
DR   EMBL; AC023754; AAG13065.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35716.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35717.1; -; Genomic_DNA.
DR   EMBL; AY062545; AAL32623.1; -; mRNA.
DR   EMBL; BT000133; AAN15452.1; -; mRNA.
DR   EMBL; AY085278; AAM62510.1; -; mRNA.
DR   EMBL; AK226561; BAE98691.1; -; mRNA.
DR   PIR; F96784; F96784.
DR   RefSeq; NP_001077827.1; NM_001084358.2.
DR   RefSeq; NP_177674.1; NM_106195.5.
DR   AlphaFoldDB; Q9FWS9; -.
DR   SMR; Q9FWS9; -.
DR   BioGRID; 29096; 25.
DR   IntAct; Q9FWS9; 22.
DR   STRING; 3702.AT1G75410.2; -.
DR   iPTMnet; Q9FWS9; -.
DR   PaxDb; Q9FWS9; -.
DR   PRIDE; Q9FWS9; -.
DR   ProteomicsDB; 222814; -.
DR   EnsemblPlants; AT1G75410.1; AT1G75410.1; AT1G75410.
DR   EnsemblPlants; AT1G75410.2; AT1G75410.2; AT1G75410.
DR   GeneID; 843877; -.
DR   Gramene; AT1G75410.1; AT1G75410.1; AT1G75410.
DR   Gramene; AT1G75410.2; AT1G75410.2; AT1G75410.
DR   KEGG; ath:AT1G75410; -.
DR   Araport; AT1G75410; -.
DR   TAIR; locus:2018398; AT1G75410.
DR   eggNOG; KOG0773; Eukaryota.
DR   HOGENOM; CLU_011058_6_1_1; -.
DR   InParanoid; Q9FWS9; -.
DR   OrthoDB; 752953at2759; -.
DR   PhylomeDB; Q9FWS9; -.
DR   PRO; PR:Q9FWS9; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FWS9; baseline and differential.
DR   Genevisible; Q9FWS9; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR006563; POX_dom.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF07526; POX; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00574; POX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..524
FT                   /note="BEL1-like homeodomain protein 3"
FT                   /id="PRO_0000315459"
FT   DNA_BIND        346..408
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          171..187
FT                   /note="SR/KY domain"
FT   REGION          195..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..300
FT                   /note="BELL domain"
FT   REGION          429..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        61
FT                   /note="V -> L (in Ref. 5; AAL32623/AAN15452)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   524 AA;  59679 MW;  94A2461E20FB3F39 CRC64;
     MAVYYPNSVG MQSLYQESIY LNEQQQQQQQ ASSSSAASFS EIVSGDVRNN EMVFIPPTSD
     VAVNGNVTVS SNDLSFHGGG LSLSLGNQIQ SAVSVSPFQY HYQNLSNQLS YNNLNPSTMS
     DENGKSLSVH QHHSDQILPS SVYNNNGNNG VGFYNNYRYE TSGFVSSVLR SRYLKPTQQL
     LDEVVSVRKD LKLGNKKMKN DKGQDFHNGS SDNITEDDKS QSQELSPSER QELQSKKSKL
     LTMVDEVDKR YNQYHHQMEA LASSFEMVTG LGAAKPYTSV ALNRISRHFR CLRDAIKEQI
     QVIRGKLGER ETSDEQGERI PRLRYLDQRL RQQRALHQQL GMVRPAWRPQ RGLPENSVSI
     LRAWLFEHFL HPYPKESEKI MLSKQTGLSK NQVANWFINA RVRLWKPMIE EMYKEEFGES
     AELLSNSNQD TKKMQETSQL KHEDSSSSQQ QNQGNNNNNI PYTSDAEQNL VFADPKPDRA
     TTGDYDSLMN YHGFGIDDYN RYVGLGNQQD GRYSNPHQLH DFVV
 
 
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