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BLH4_ARATH
ID   BLH4_ARATH              Reviewed;         627 AA.
AC   Q94KL5; O64826; Q56WI2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=BEL1-like homeodomain protein 4;
DE            Short=BEL1-like protein 4;
DE   AltName: Full=Protein SAWTOOTH 2;
GN   Name=BLH4; Synonyms=SAW2; OrderedLocusNames=At2g23760; ORFNames=F27L4.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pidkowich M.S., Samach A., Kohalmi S.E., Crosby W.L., Haughn G.W.;
RT   "KNAT1-interacting homeodomain proteins in Arabidopsis.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-627.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY ORGANIZATION.
RX   PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA   Smith H.M.S., Campbell B.C.C., Hake S.;
RT   "Competence to respond to floral inductive signals requires the homeobox
RT   genes PENNYWISE and POUND-FOOLISH.";
RL   Curr. Biol. 14:812-817(2004).
RN   [7]
RP   INTERACTION WITH OFP1; OFP2 AND OFP5.
RX   PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA   Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT   "A central role of Arabidopsis thaliana ovate family proteins in networking
RT   and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN   [8]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17873098; DOI=10.1105/tpc.106.048769;
RA   Kumar R., Kushalappa K., Godt D., Pidkowich M.S., Pastorelli S.,
RA   Hepworth S.R., Haughn G.W.;
RT   "The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act
RT   redundantly to regulate KNOX expression spatially in leaf margins.";
RL   Plant Cell 19:2719-2735(2007).
RN   [9]
RP   INTERACTION WITH KNATM.
RX   PubMed=18398054; DOI=10.1105/tpc.108.058495;
RA   Magnani E., Hake S.;
RT   "KNOX lost the OX: the Arabidopsis KNATM gene defines a novel class of KNOX
RT   transcriptional regulators missing the homeodomain.";
RL   Plant Cell 20:875-887(2008).
CC   -!- FUNCTION: Transcription factor that establishes leaf shape by
CC       repressing growth in specific subdomains of the leaf. Negatively
CC       regulates knox homeobox gene KNAT1/BP expression.
CC       {ECO:0000269|PubMed:17873098}.
CC   -!- SUBUNIT: May form heterodimeric complexes with TALE/KNOX proteins (By
CC       similarity). Interacts with OFP1, OFP2 and OFP5 (PubMed:15781858).
CC       Interacts with KNATM, isoform KNATM-B (PubMed:18398054). {ECO:0000250,
CC       ECO:0000269|PubMed:15781858, ECO:0000269|PubMed:18398054}.
CC   -!- INTERACTION:
CC       Q94KL5; Q9FG01: ATO; NbExp=3; IntAct=EBI-1153797, EBI-4475455;
CC       Q94KL5; Q9SU72: EDS1; NbExp=3; IntAct=EBI-1153797, EBI-1390454;
CC       Q94KL5; Q9LQT8: GAI; NbExp=3; IntAct=EBI-1153797, EBI-963606;
CC       Q94KL5; P46639: KNAT1; NbExp=3; IntAct=EBI-1153797, EBI-530486;
CC       Q94KL5; Q9SLH3: RGA; NbExp=3; IntAct=EBI-1153797, EBI-963624;
CC       Q94KL5; Q8GXW1: RGL2; NbExp=3; IntAct=EBI-1153797, EBI-963665;
CC       Q94KL5; Q38874: STM; NbExp=3; IntAct=EBI-1153797, EBI-530523;
CC       Q94KL5; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-1153797, EBI-4426557;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in lateral organs.
CC       {ECO:0000269|PubMed:17873098}.
CC   -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC       between the TALE/BELL proteins and the TALE/KNOX proteins.
CC   -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD94844.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF353092; AAK43834.1; -; mRNA.
DR   EMBL; AC004482; AAC17087.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07486.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07487.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07488.1; -; Genomic_DNA.
DR   EMBL; AY058179; AAL25593.1; -; mRNA.
DR   EMBL; AY142019; AAM98283.1; -; mRNA.
DR   EMBL; AK222058; BAD94844.1; ALT_INIT; mRNA.
DR   PIR; T02415; T02415.
DR   RefSeq; NP_001031404.1; NM_001036327.2.
DR   RefSeq; NP_179956.1; NM_127939.3.
DR   RefSeq; NP_850044.1; NM_179713.3.
DR   AlphaFoldDB; Q94KL5; -.
DR   SMR; Q94KL5; -.
DR   BioGRID; 2260; 46.
DR   IntAct; Q94KL5; 46.
DR   STRING; 3702.AT2G23760.2; -.
DR   PaxDb; Q94KL5; -.
DR   PRIDE; Q94KL5; -.
DR   ProteomicsDB; 240802; -.
DR   EnsemblPlants; AT2G23760.1; AT2G23760.1; AT2G23760.
DR   EnsemblPlants; AT2G23760.2; AT2G23760.2; AT2G23760.
DR   EnsemblPlants; AT2G23760.3; AT2G23760.3; AT2G23760.
DR   GeneID; 816908; -.
DR   Gramene; AT2G23760.1; AT2G23760.1; AT2G23760.
DR   Gramene; AT2G23760.2; AT2G23760.2; AT2G23760.
DR   Gramene; AT2G23760.3; AT2G23760.3; AT2G23760.
DR   KEGG; ath:AT2G23760; -.
DR   Araport; AT2G23760; -.
DR   TAIR; locus:2049035; AT2G23760.
DR   eggNOG; KOG0773; Eukaryota.
DR   HOGENOM; CLU_011058_2_0_1; -.
DR   InParanoid; Q94KL5; -.
DR   PhylomeDB; Q94KL5; -.
DR   PRO; PR:Q94KL5; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q94KL5; baseline and differential.
DR   Genevisible; Q94KL5; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009965; P:leaf morphogenesis; IGI:TAIR.
DR   GO; GO:0048363; P:mucilage pectin metabolic process; IMP:TAIR.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR006563; POX_dom.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF07526; POX; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00574; POX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..627
FT                   /note="BEL1-like homeodomain protein 4"
FT                   /id="PRO_0000315460"
FT   DNA_BIND        424..486
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          206..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..257
FT                   /note="SR/KY domain"
FT   REGION          263..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..373
FT                   /note="BELL domain"
FT   REGION          494..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..530
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        228
FT                   /note="A -> G (in Ref. 1; AAK43834)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   627 AA;  69271 MW;  C2AC0D7C97111192 CRC64;
     MGLATTTSSM SQDYHHHQGI FSFSNGFHRS SSTTHQEEVD ESAVVSGAQI PVYETAGMLS
     EMFAYPGGGG GGSGGEILDQ STKQLLEQQN RHNNNNNSTL HMLLPNHHQG FAFTDENTMQ
     PQQQQHFTWP SSSSDHHQNR DMIGTVHVEG GKGLSLSLSS SLAAAKAEEY RSIYCAAVDG
     TSSSSNASAH HHQFNQFKNL LLENSSSQHH HHQVVGHFGS SSSSPMAASS SIGGIYTLRN
     SKYTKPAQEL LEEFCSVGRG HFKKNKLSRN NSNPNTTGGG GGGGSSSSAG TANDSPPLSP
     ADRIEHQRRK VKLLSMLEEV DRRYNHYCEQ MQMVVNSFDQ VMGYGAAVPY TTLAQKAMSR
     HFRCLKDAVA VQLKRSCELL GDKEAAGAAS SGLTKGETPR LRLLEQSLRQ QRAFHHMGMM
     EQEAWRPQRG LPERSVNILR AWLFEHFLNP YPSDADKHLL ARQTGLSRNQ VSNWFINARV
     RLWKPMVEEM YQQEAKEREE AEEENENQQQ QRRQQQTNNN DTKPNNNENN FTVITAQTPT
     TMTSTHHEND SSFLSSVAAA SHGGSDAFTV ATCQQDVSDF HVDGDGVNVI RFGTKQTGDV
     SLTLGLRHSG NIPDKNTSFS VRDFGDF
 
 
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