BLH5_ARATH
ID BLH5_ARATH Reviewed; 431 AA.
AC Q8S897; C0SV62; Q4PSU3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=BEL1-like homeodomain protein 5;
DE Short=BEL1-like protein 5;
GN Name=BLH5; OrderedLocusNames=At2g27220; ORFNames=T22O13.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA Smith H.M.S., Campbell B.C.C., Hake S.;
RT "Competence to respond to floral inductive signals requires the homeobox
RT genes PENNYWISE and POUND-FOOLISH.";
RL Curr. Biol. 14:812-817(2004).
RN [6]
RP INTERACTION WITH OFP1.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
CC -!- SUBUNIT: May form heterodimeric complexes with TALE/KNOX proteins (By
CC similarity). Interacts with OFP1. {ECO:0000250,
CC ECO:0000269|PubMed:15781858}.
CC -!- INTERACTION:
CC Q8S897; P46640: KNAT2; NbExp=3; IntAct=EBI-1153992, EBI-1153809;
CC Q8S897; P48000: KNAT3; NbExp=3; IntAct=EBI-1153992, EBI-1153908;
CC Q8S897; Q84JS6: KNAT6; NbExp=3; IntAct=EBI-1153992, EBI-530499;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8S897-1; Sequence=Displayed;
CC -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC between the TALE/BELL proteins and the TALE/KNOX proteins.
CC -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR EMBL; AC007290; AAM15481.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07955.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62400.1; -; Genomic_DNA.
DR EMBL; DQ056543; AAY78695.1; -; mRNA.
DR EMBL; AB493565; BAH30403.1; -; mRNA.
DR RefSeq; NP_001318297.1; NM_001336110.1. [Q8S897-1]
DR RefSeq; NP_180290.2; NM_128280.3. [Q8S897-1]
DR AlphaFoldDB; Q8S897; -.
DR SMR; Q8S897; -.
DR BioGRID; 2616; 10.
DR IntAct; Q8S897; 7.
DR STRING; 3702.AT2G27220.2; -.
DR PaxDb; Q8S897; -.
DR PRIDE; Q8S897; -.
DR EnsemblPlants; AT2G27220.1; AT2G27220.1; AT2G27220. [Q8S897-1]
DR EnsemblPlants; AT2G27220.3; AT2G27220.3; AT2G27220. [Q8S897-1]
DR GeneID; 817264; -.
DR Gramene; AT2G27220.1; AT2G27220.1; AT2G27220. [Q8S897-1]
DR Gramene; AT2G27220.3; AT2G27220.3; AT2G27220. [Q8S897-1]
DR KEGG; ath:AT2G27220; -.
DR Araport; AT2G27220; -.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_011058_5_2_1; -.
DR InParanoid; Q8S897; -.
DR PRO; PR:Q8S897; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S897; baseline and differential.
DR Genevisible; Q8S897; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR006563; POX_dom.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF07526; POX; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00574; POX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..431
FT /note="BEL1-like homeodomain protein 5"
FT /id="PRO_0000315461"
FT DNA_BIND 228..290
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 80..96
FT /note="SR/KY domain"
FT REGION 128..199
FT /note="BELL domain"
FT REGION 302..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 239
FT /note="A -> V (in Ref. 1; AAM15481)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 48818 MW; 3EB7991CBD428F69 CRC64;
MAAFFLGESE MREHSSDLFM MTLNPFREQT TTTNAHDDHF YNLCFGSQQY RPRDEVGHIE
QGNSSISTFS NGGVFRALAP IYLKAAQELL NEIVNVGNGS HGAKQERPVS KESTIYGVED
INGGYKPGVA ALQMKKAKLI SMGEMVEQRY KQYHDQMQTI ISSFEQAAGL GSANSYTHMA
LQTISKQFRA VKDMISLQIK QINKLLGQKE FDEQLKKLGK MAHHHSNAWR PQRGLPEKAV
SVLRSWLFEH FLHPYPRDLD KVMLAKQTGL TKSQVSNWFI NARVRMWKPL VEELYSEEMD
IEESRKGSDR YSTKGSSSKQ PYNNTTSNES SNTILPAFRQ GFTETETPRQ NSSSSCSVVM
RFTKQHMNQA NFINFNGGFE NYHTMDGNSV SLSLGLPHSC DQTFNNIHFE STSHGTENSA
IYSSSTYQIM D
