BLH6_ARATH
ID BLH6_ARATH Reviewed; 532 AA.
AC O65685;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=BEL1-like homeodomain protein 6;
DE Short=BEL1-like protein 6;
GN Name=BLH6; OrderedLocusNames=At4g34610; ORFNames=T4L20.190;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA Smith H.M.S., Campbell B.C.C., Hake S.;
RT "Competence to respond to floral inductive signals requires the homeobox
RT genes PENNYWISE and POUND-FOOLISH.";
RL Curr. Biol. 14:812-817(2004).
RN [5]
RP INTERACTION WITH OFP2; OFP4 AND OFP5.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
CC -!- SUBUNIT: May form heterodimeric complexes with TALE/KNOX proteins (By
CC similarity). Interacts with OFP2, OFP4, and OFP5. {ECO:0000250,
CC ECO:0000269|PubMed:15781858}.
CC -!- INTERACTION:
CC O65685; P46639: KNAT1; NbExp=4; IntAct=EBI-1153881, EBI-530486;
CC O65685; P46640: KNAT2; NbExp=3; IntAct=EBI-1153881, EBI-1153809;
CC O65685; Q84JS6: KNAT6; NbExp=3; IntAct=EBI-1153881, EBI-530499;
CC O65685; Q38874: STM; NbExp=3; IntAct=EBI-1153881, EBI-530523;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC between the TALE/BELL proteins and the TALE/KNOX proteins.
CC -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR EMBL; AL023094; CAA18840.1; -; Genomic_DNA.
DR EMBL; AL161585; CAB80178.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86399.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86400.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66951.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66952.1; -; Genomic_DNA.
DR EMBL; BT012291; AAS76778.1; -; mRNA.
DR PIR; T05281; T05281.
DR RefSeq; NP_001119116.1; NM_001125644.1.
DR RefSeq; NP_001328814.1; NM_001342295.1.
DR RefSeq; NP_001328815.1; NM_001342296.1.
DR RefSeq; NP_195187.1; NM_119627.4.
DR AlphaFoldDB; O65685; -.
DR SMR; O65685; -.
DR BioGRID; 14895; 17.
DR IntAct; O65685; 17.
DR STRING; 3702.AT4G34610.1; -.
DR PaxDb; O65685; -.
DR PRIDE; O65685; -.
DR ProteomicsDB; 240355; -.
DR EnsemblPlants; AT4G34610.1; AT4G34610.1; AT4G34610.
DR EnsemblPlants; AT4G34610.2; AT4G34610.2; AT4G34610.
DR EnsemblPlants; AT4G34610.3; AT4G34610.3; AT4G34610.
DR EnsemblPlants; AT4G34610.4; AT4G34610.4; AT4G34610.
DR GeneID; 829613; -.
DR Gramene; AT4G34610.1; AT4G34610.1; AT4G34610.
DR Gramene; AT4G34610.2; AT4G34610.2; AT4G34610.
DR Gramene; AT4G34610.3; AT4G34610.3; AT4G34610.
DR Gramene; AT4G34610.4; AT4G34610.4; AT4G34610.
DR KEGG; ath:AT4G34610; -.
DR Araport; AT4G34610; -.
DR TAIR; locus:2139614; AT4G34610.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_011058_6_0_1; -.
DR InParanoid; O65685; -.
DR OMA; RGNEYAT; -.
DR OrthoDB; 311531at2759; -.
DR PhylomeDB; O65685; -.
DR PRO; PR:O65685; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O65685; baseline and differential.
DR Genevisible; O65685; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR006563; POX_dom.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF07526; POX; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00574; POX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..532
FT /note="BEL1-like homeodomain protein 6"
FT /id="PRO_0000315462"
FT DNA_BIND 314..376
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 144..160
FT /note="SR/KY domain"
FT REGION 170..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..271
FT /note="BELL domain"
FT REGION 385..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 59609 MW; 1C0FC7154A0D366D CRC64;
MENYPETQFI PGDSMIQNAI VSYSEESAGR ERRTEANNVS ASQERQALSR FGGVPQMQNI
GQDFGSWRDQ ASDRNGFQLM SAMAGATGIL QTGQGLSLSL GSQILPGIHQ ISHQNMAPRG
NEYATQSFPG GNQNLDVVRT IPNSKYLKAA QQLLDEAVNV KKALKQFQAE GDKNNENPQE
PNQSTQDSST NPPADISQSE RQEMQSKLTK LLSMLDEVDR RYKQYYQQMQ IVVSSFDVIA
GYGAAKPYTA LALQTISRHF RSLRDAISGQ ILVLRKCLGE QQDGSDGKRV GIISRLKYVD
QHLRQQRGFM QPQAWRPQRG LPENSVLILR AWLFEHFLHP YPKDSDKIML ARQTGLSRGQ
VSNWFINARV RLWKPMVEEI YKEEFTENDS NSSSENTPKM SEIGPVAADD EDRAREFSQD
QTKPDHGHGY GEETRGMVQG SHMDGRRFMA VEPTYHVADT SRLGRGDVSL TLGLQNSQGQ
DNVVAMSSEA YNNFSGVDIY ENAIPGDEME YVNPGSRQNR INSSQLVHDF VA
