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BLH8_ARATH
ID   BLH8_ARATH              Reviewed;         584 AA.
AC   Q9SJJ3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=BEL1-like homeodomain protein 8;
DE            Short=BEL1-like protein 8;
DE   AltName: Full=Protein POUND-FOOLISH;
GN   Name=BLH8; Synonyms=PNF; OrderedLocusNames=At2g27990; ORFNames=T1E2.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   GENE FAMILY ORGANIZATION, AND FUNCTION.
RX   PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA   Smith H.M.S., Campbell B.C.C., Hake S.;
RT   "Competence to respond to floral inductive signals requires the homeobox
RT   genes PENNYWISE and POUND-FOOLISH.";
RL   Curr. Biol. 14:812-817(2004).
RN   [6]
RP   FUNCTION, AND INTERACTION WITH STM AND KNAT1/BP.
RX   PubMed=16741748; DOI=10.1007/s00425-006-0298-9;
RA   Kanrar S., Onguka O., Smith H.M.S.;
RT   "Arabidopsis inflorescence architecture requires the activities of KNOX-
RT   BELL homeodomain heterodimers.";
RL   Planta 224:1163-1173(2006).
CC   -!- FUNCTION: Required for specifying floral primordia and establishing
CC       early internode patterning events during inflorescence development.
CC       {ECO:0000269|PubMed:15120075, ECO:0000269|PubMed:16741748}.
CC   -!- SUBUNIT: May form heterodimeric complex with the TALE/KNOX proteins STM
CC       and KNAT1/BP.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC       between the TALE/BELL proteins and the TALE/KNOX proteins.
CC   -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR   EMBL; AC006929; AAD21503.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08067.1; -; Genomic_DNA.
DR   EMBL; AK119153; BAC43723.1; -; mRNA.
DR   EMBL; BT005921; AAO64856.1; -; mRNA.
DR   PIR; D84679; D84679.
DR   RefSeq; NP_180366.1; NM_128358.3.
DR   AlphaFoldDB; Q9SJJ3; -.
DR   SMR; Q9SJJ3; -.
DR   BioGRID; 2693; 6.
DR   IntAct; Q9SJJ3; 7.
DR   STRING; 3702.AT2G27990.1; -.
DR   PaxDb; Q9SJJ3; -.
DR   PRIDE; Q9SJJ3; -.
DR   ProteomicsDB; 240803; -.
DR   EnsemblPlants; AT2G27990.1; AT2G27990.1; AT2G27990.
DR   GeneID; 817343; -.
DR   Gramene; AT2G27990.1; AT2G27990.1; AT2G27990.
DR   KEGG; ath:AT2G27990; -.
DR   Araport; AT2G27990; -.
DR   TAIR; locus:2057856; AT2G27990.
DR   eggNOG; KOG0773; Eukaryota.
DR   HOGENOM; CLU_467247_0_0_1; -.
DR   InParanoid; Q9SJJ3; -.
DR   OrthoDB; 382655at2759; -.
DR   PhylomeDB; Q9SJJ3; -.
DR   PRO; PR:Q9SJJ3; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SJJ3; baseline and differential.
DR   Genevisible; Q9SJJ3; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0010229; P:inflorescence development; IGI:TAIR.
DR   GO; GO:0080006; P:internode patterning; IGI:TAIR.
DR   GO; GO:0010076; P:maintenance of floral meristem identity; IGI:TAIR.
DR   GO; GO:0010077; P:maintenance of inflorescence meristem identity; IGI:TAIR.
DR   GO; GO:0007389; P:pattern specification process; IGI:TAIR.
DR   GO; GO:1905393; P:plant organ formation; IGI:TAIR.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0010223; P:secondary shoot formation; IGI:TAIR.
DR   GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IGI:TAIR.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR006563; POX_dom.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF07526; POX; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00574; POX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..584
FT                   /note="BEL1-like homeodomain protein 8"
FT                   /id="PRO_0000315464"
FT   DNA_BIND        424..486
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          266..282
FT                   /note="SR/KY domain"
FT   REGION          292..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..387
FT                   /note="BELL domain"
FT   REGION          503..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  65775 MW;  E42EB1B86BEAA535 CRC64;
     MDMIKPDFQQ IRRDKFRVEQ MNDFPNTWTQ QQHQNIRIPN NLDLIGILQN QISVPVQTDL
     YQDSAATFMN MPQSIHRDPQ GPSNWRISDL SQPSTVNHGY DQAGIRPNNV ADLLSDHFSS
     RNQILDRPLY VGRDSIPQSS MIRRSEVSCL DDNQKGCVTV ACSGTGNEIL RSSYDQGSSS
     GSYRGEFSFL PSLENQSVAH NASNWNHGPV NVTATSHTNS KKGFPLSLLS DIPPSRDVGN
     AAVLSTMNIH GPLGPFTGYA SILKSSRFLE PAQKMLEEFC ISYASKIISR SESTSMEDDD
     DDDDNLSGFS SSSEPLEPKN RLKKAKLLFL QEEVCKWYKL YNHQLQTVMS SFNTVAGLNT
     ATPYISLALK RTSRSFKALR TAIAEHVKQI SSHSSNGNNN NRFQKRQRSL IGNNVGFESQ
     QQHIWRPQRG LPERAVAVLR AWLFDHFLHP YPTDSDKQML ATQTGLSRNQ VSNWFINARV
     RLWKPMVEEI HTLETKAIKN ADTSHNIEPS NRPNTVSSPS HEQTLTGLSG TKRSRLEYMD
     MVGFNRGNVS LTLELRRGVD NVIQTQTQDH QFGTGSQMFH DFVG
 
 
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