BLI1_YEAST
ID BLI1_YEAST Reviewed; 113 AA.
AC P35727; D6VXM6;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit BLI1;
DE Short=BLOC-1 subunit BLI1;
DE AltName: Full=BLOC-1 interactor 1;
GN Name=BLI1; OrderedLocusNames=YKL061W; ORFNames=YKL321;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091862; DOI=10.1002/yea.320100008;
RA Rasmussen S.W.;
RT "Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and
RT TOA2 genes, an open reading frame (ORF) similar to a translationally
RT controlled tumour protein, one ORF containing motifs also found in plant
RT storage proteins and 13 ORFs with weak or no homology to known proteins.";
RL Yeast 10:S63-S68(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND FUNCTION.
RX PubMed=21159114; DOI=10.1111/j.1600-0854.2010.01151.x;
RA Hayes M.J., Bryon K., Satkurunathan J., Levine T.P.;
RT "Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as
RT conserved interactors of BLOC-1.";
RL Traffic 12:260-268(2011).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in endosomal cargo sorting.
CC {ECO:0000269|PubMed:21159114}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC and VAB2. {ECO:0000269|PubMed:21159114}.
CC -!- INTERACTION:
CC P35727; P48232: SNN1; NbExp=3; IntAct=EBI-26722, EBI-28775;
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the BLI1 family. {ECO:0000305}.
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DR EMBL; X75781; CAA53422.1; -; Genomic_DNA.
DR EMBL; Z28061; CAA81898.1; -; Genomic_DNA.
DR EMBL; AY558312; AAS56638.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09096.1; -; Genomic_DNA.
DR PIR; S37883; S37883.
DR RefSeq; NP_012862.1; NM_001179627.1.
DR AlphaFoldDB; P35727; -.
DR BioGRID; 34072; 81.
DR ComplexPortal; CPX-1153; BLOC-1 complex.
DR DIP; DIP-1992N; -.
DR IntAct; P35727; 10.
DR MINT; P35727; -.
DR STRING; 4932.YKL061W; -.
DR MaxQB; P35727; -.
DR PaxDb; P35727; -.
DR PRIDE; P35727; -.
DR EnsemblFungi; YKL061W_mRNA; YKL061W; YKL061W.
DR GeneID; 853804; -.
DR KEGG; sce:YKL061W; -.
DR SGD; S000001544; BLI1.
DR VEuPathDB; FungiDB:YKL061W; -.
DR eggNOG; ENOG502S8B7; Eukaryota.
DR HOGENOM; CLU_168467_0_0_1; -.
DR InParanoid; P35727; -.
DR OMA; AVANHEW; -.
DR BioCyc; YEAST:G3O-31859-MON; -.
DR PRO; PR:P35727; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P35727; protein.
DR GO; GO:0031083; C:BLOC-1 complex; IDA:SGD.
DR GO; GO:0005768; C:endosome; IDA:ComplexPortal.
DR GO; GO:0007032; P:endosome organization; IMP:SGD.
DR GO; GO:0032880; P:regulation of protein localization; IMP:SGD.
DR InterPro; IPR020491; BLI1.
DR Pfam; PF17324; BLI1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Endosome; Reference proteome; Transport.
FT CHAIN 1..113
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit BLI1"
FT /id="PRO_0000203176"
FT COILED 57..97
FT /evidence="ECO:0000255"
SQ SEQUENCE 113 AA; 13521 MW; A4BBFE37A4C5282A CRC64;
MGEQNKLYYD VEKLVNSLQE SFDLDCAQSV SLFTSKSRSN EAWLEELENK FKLKDDVELD
DVENLRAEID MKLNMLEDKV SYYERLYKEL EEFQNEIKIK TVVNNRRQSR TPK
