ID   BLI4_NEUCR              Reviewed;         412 AA.
AC   Q92247; Q7RVJ1;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Putative oxidoreductase bli-4, mitochondrial;
DE            EC=1.-.-.-;
DE   AltName: Full=Blue light-induced protein 4;
DE   Flags: Precursor;
GN   Name=bli-4; ORFNames=B24M22.250, NCU08699;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 56-64.
RC   STRAIN=STA;
RX   PubMed=8842141; DOI=10.1007/bf02173767;
RA   Bruchez J.J.P., Eberle J., Kohler W., Kruft V., Radford A., Russo V.E.A.;
RT   "bli-4, a gene that is rapidly induced by blue light, encodes a novel
RT   mitochondrial, short-chain alcohol dehydrogenase-like protein in Neurospora
RT   crassa.";
RL   Mol. Gen. Genet. 252:223-229(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May play a role as an NAD-dependent dehydrogenase in the
CC       mitochondria.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- INDUCTION: By blue light.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; X89499; CAA61670.1; -; Genomic_DNA.
DR   EMBL; AL390354; CAB99393.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA34324.3; -; Genomic_DNA.
DR   PIR; S72617; S72617.
DR   RefSeq; XP_963560.3; XM_958467.3.
DR   AlphaFoldDB; Q92247; -.
DR   SMR; Q92247; -.
DR   BioGRID; 1981008; 1.
DR   STRING; 5141.EFNCRP00000008621; -.
DR   EnsemblFungi; EAA34324; EAA34324; NCU08699.
DR   GeneID; 3879739; -.
DR   KEGG; ncr:NCU08699; -.
DR   VEuPathDB; FungiDB:NCU08699; -.
DR   HOGENOM; CLU_010194_44_6_1; -.
DR   InParanoid; Q92247; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; Oxidoreductase;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..55
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:8842141"
FT   CHAIN           56..412
FT                   /note="Putative oxidoreductase bli-4, mitochondrial"
FT                   /id="PRO_0000031964"
FT   ACT_SITE        269
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         101..126
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   412 AA;  44634 MW;  DB92A9ABBD696963 CRC64;
     MSTKLCQRIA RTATLSPTSL VPRSSRLIPI VSSAAVRPSS AIPTRRPFST TESRYLANVQ
     AGMDKIRDAI AENFGGPAHN IGTTSFSLDD TPDLSGKVAV ITGGSEGIGY GVAYTLIKHN
     LSKLFILSRK REVFDGALAS IASELGQDKA DRVHWIQCNL EDWAQTAVVA EQIKKDTDRL
     DILVNNSGRG IMTAGLTSYG VDKHMATNHM GHVVLTSHLL PLLQKTAEET GETVRISNQS
     SNLHSAAPKG TQFKSLEEIN EDVGPNGQYG RSKLAGILYA RYFDREVTRK MEGSKGRVVM
     NATHPGFVST KQSVKDIHEP YPISGFAISH LAEPFKKDQF EGAVPTVYAV TMANEGGQWI
     CAPAKAEAGT DLAQSDELAD NLMELTRKII SEKTWPKSVA KGCPMDDVVV HV