BLML_HUMAN
ID BLML_HUMAN Reviewed; 500 AA.
AC A8MY62;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Putative beta-lactamase-like 1;
GN Name=LACTBL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-130.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta-lactamase family. {ECO:0000305}.
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DR EMBL; AL035704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DR731278; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; A8MY62; -.
DR SMR; A8MY62; -.
DR STRING; 9606.ENSP00000402297; -.
DR iPTMnet; A8MY62; -.
DR PhosphoSitePlus; A8MY62; -.
DR BioMuta; LACTBL1; -.
DR MassIVE; A8MY62; -.
DR PaxDb; A8MY62; -.
DR PeptideAtlas; A8MY62; -.
DR PRIDE; A8MY62; -.
DR ProteomicsDB; 2376; -.
DR Antibodypedia; 74317; 7 antibodies from 4 providers.
DR Ensembl; ENST00000618559.1; ENSP00000483725.1; ENSG00000215906.8.
DR UCSC; uc057dej.1; human.
DR GeneCards; LACTBL1; -.
DR HGNC; HGNC:35445; LACTBL1.
DR HPA; ENSG00000215906; Tissue enriched (retina).
DR neXtProt; NX_A8MY62; -.
DR VEuPathDB; HostDB:ENSG00000215906; -.
DR eggNOG; ENOG502R2HC; Eukaryota.
DR GeneTree; ENSGT00450000040404; -.
DR HOGENOM; CLU_042163_1_0_1; -.
DR InParanoid; A8MY62; -.
DR PhylomeDB; A8MY62; -.
DR SignaLink; A8MY62; -.
DR ChiTaRS; LACTBL1; human.
DR Pharos; A8MY62; Tdark.
DR PRO; PR:A8MY62; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A8MY62; protein.
DR Bgee; ENSG00000215906; Expressed in right testis and 1 other tissue.
DR ExpressionAtlas; A8MY62; baseline and differential.
DR Gene3D; 3.40.710.10; -; 1.
DR InterPro; IPR001466; Beta-lactam-related.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR Pfam; PF00144; Beta-lactamase; 1.
DR SUPFAM; SSF56601; SSF56601; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..500
FT /note="Putative beta-lactamase-like 1"
FT /id="PRO_0000343690"
FT CONFLICT 92..95
FT /note="RLWE -> LPWH (in Ref. 2; DR731278)"
FT /evidence="ECO:0000305"
FT CONFLICT 110..112
FT /note="AST -> SSP (in Ref. 2; DR731278)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="Q -> E (in Ref. 2; DR731278)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="I -> M (in Ref. 2; DR731278)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 54653 MW; 5AA90CDAB9411D66 CRC64;
MCPRHPEPVP LAHPLPVLKE ALEKVDQILR QAMSAPGVAA MSAVVIHNDT VLWTGNFGKK
NGSDPASGAP NEYTMYRISS ISKIFPVLML YRLWEEGIVA SLDDPLERYA STFTINNPLG
LASAEQQGLI LRRMASQLSG LPRRLRSTSL LWKGSTQEAL NLLKDDVLVV DPGTRCHYST
LAFSLLAHVL AAHTAQGDYQ RWVSENVLEP LGMADTGFDL TPDVRARLAA GFYGSGRPAP
LYDLGWYRPS GQMYSTAADL AKLAVALLGG GPRRLLRPDA AKTLLAPLLA CPGAYFANET
GTPWEFHAQR GYRVVRKDGD LDGYAATFSL VPPLRLGLVL LLAGPRPPGP DLVARAYDEL
LPALERALRE AEPGPAPPPT AHPFAGYFTF ANLTFYEVRA GPAGELRLRQ FGPRVEALVP
PAFRTLALRH LHGRVFQLHV AHEFPCALPL GDAWLSLEAQ HGQLVNFYPL DHHGLSPGFD
VPGLNTYRVL RLRGKPVFKT
