BLMP1_CAEEL
ID BLMP1_CAEEL Reviewed; 817 AA.
AC Q93560; B7WN98;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=B lymphocyte-induced maturation protein 1 homolog {ECO:0000312|WormBase:F25D7.3a};
GN Name=blmp-1 {ECO:0000312|WormBase:F25D7.3a};
GN ORFNames=F25D7.3 {ECO:0000312|WormBase:F25D7.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|EMBL:CAB01695.1};
RN [1] {ECO:0000312|EMBL:CAB01695.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAB01695.1};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=21408209; DOI=10.1371/journal.pgen.1002010;
RA Nelson M.D., Zhou E., Kiontke K., Fradin H., Maldonado G., Martin D.,
RA Shah K., Fitch D.H.;
RT "A bow-tie genetic architecture for morphogenesis suggested by a genome-
RT wide RNAi screen in Caenorhabditis elegans.";
RL PLoS Genet. 7:E1002010-E1002010(2011).
RN [3] {ECO:0000305}
RP FUNCTION, INTERACTION WITH DRE-1, DEVELOPMENTAL STAGE, UBIQUITINATION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=24613396; DOI=10.1016/j.devcel.2014.01.028;
RA Horn M., Geisen C., Cermak L., Becker B., Nakamura S., Klein C., Pagano M.,
RA Antebi A.;
RT "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans
RT developmental timing and maturation.";
RL Dev. Cell 28:697-710(2014).
RN [4] {ECO:0000305}
RP FUNCTION, INTERACTION WITH DRE-1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=24968003; DOI=10.1371/journal.pgen.1004428;
RA Huang T.F., Cho C.Y., Cheng Y.T., Huang J.W., Wu Y.Z., Yeh A.Y.,
RA Nishiwaki K., Chang S.C., Wu Y.C.;
RT "BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C.
RT elegans.";
RL PLoS Genet. 10:E1004428-E1004428(2014).
RN [5] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=26234645; DOI=10.1016/j.bbagrm.2015.07.012;
RA Yang J., Fong H.T., Xie Z., Tan J.W., Inoue T.;
RT "Direct and positive regulation of Caenorhabditis elegans bed-3 by
RT PRDM1/BLIMP1 ortholog BLMP-1.";
RL Biochim. Biophys. Acta 1849:1229-1236(2015).
RN [6] {ECO:0000305}
RP FUNCTION, INTERACTION WITH LDB-1 AND HAM-3, AND DISRUPTION PHENOTYPE.
RX PubMed=32417234; DOI=10.1016/j.bbagrm.2020.194577;
RA Fong H.T., Hagen T., Inoue T.;
RT "LDB1 and the SWI/SNF complex participate in both transcriptional
RT activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.";
RL Biochim. Biophys. Acta 1863:194577-194577(2020).
CC -!- FUNCTION: Transcription factor which binds to enhancer elements in the
CC promoter region of genes (PubMed:26234645). Regulates the expression of
CC the transcription factor bed-3 to control vulval development
CC (PubMed:26234645, PubMed:32417234). Promotes terminal differentiation
CC in the hypodermis and is involved in regulation of gonadal outgrowth
CC and entry into the dauer stage (PubMed:24613396). Regulates the timing
CC of dorsalward migration of the distal tip cells of the hermaphrodite
CC gonad by inhibiting precocious unc-5 and lin-29 expression which in
CC turn prevents early dorsalward turning (PubMed:24968003). Plays a role
CC in male tail tip morphogenesis (PubMed:21408209).
CC {ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:24613396,
CC ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:26234645}.
CC -!- SUBUNIT: Interacts with dre-1; the interaction targets blmp-1 for
CC proteasomal degradation (PubMed:24613396, PubMed:24968003). Interacts
CC with ldb-1 and ham-3 (PubMed:32417234). {ECO:0000269|PubMed:24613396,
CC ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:32417234}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21408209,
CC ECO:0000269|PubMed:24968003}. Cytoplasm {ECO:0000269|PubMed:21408209}.
CC Note=Localizes to the nucleus and cytoplasm in hyp8-11 tail tip cells
CC throughout development, but cytoplasmic localization is most prominent
CC during male tail tip retraction. {ECO:0000269|PubMed:21408209}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000312|WormBase:F25D7.3a};
CC IsoId=Q93560-1; Sequence=Displayed;
CC Name=2 {ECO:0000312|WormBase:F25D7.3b};
CC IsoId=Q93560-2; Sequence=VSP_057061;
CC -!- TISSUE SPECIFICITY: Expressed in hypodermal, vulval, intestinal and
CC distal tip cells. {ECO:0000269|PubMed:24968003}.
CC -!- DEVELOPMENTAL STAGE: In distal tip cells, expressed from mid-L2 when
CC gonadal outgrowth initiates (PubMed:24613396). By mid-L3, just prior to
CC the dorsal gonadal turn, levels drop dramatically (PubMed:24968003). In
CC seam and hypodermal cells, levels are largely constant throughout
CC larval development except for a transient peak early in L4
CC (PubMed:24613396). {ECO:0000269|PubMed:24613396,
CC ECO:0000269|PubMed:24968003}.
CC -!- PTM: Ubiquitinated by the SCF(dre-1) complex, leading to its
CC degradation by the proteasome. {ECO:0000269|PubMed:24613396}.
CC -!- DISRUPTION PHENOTYPE: Gonadal migration defects with premature dorsal
CC turning of distal tip cells in the hermaphrodite gonad
CC (PubMed:24613396, PubMed:24968003). Defective dauer formation,
CC shortened lifespan and retarded terminal differentiation of seam cells
CC with incomplete adult alae synthesis (PubMed:24613396). Suppresses the
CC precocious seam cell terminal differentiation and gonadal migration
CC defects seen in dre-1 mutants (PubMed:24613396). Weak dumpy phenotype
CC and partially penetrant embryonic lethality (PubMed:24968003). Reduced
CC expression of the transcription factor bed-3 which is involved in
CC vulval development and failed division of vulval precursor cell
CC descendents (PubMed:26234645). RNAi-mediated knockdown impairs the
CC expression of several hypodermis-specific genes; reduces levels of clo-
CC 124 mRNA and increases levels of lin-29 mRNA (PubMed:32417234). RNAi-
CC mediated knockdown results in the precocious onset of tail tip
CC retraction resulting in over-retracted and shortened adult male tails
CC (also known as the Ore phenotype) (PubMed:21408209).
CC {ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:24613396,
CC ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:26234645,
CC ECO:0000269|PubMed:32417234}.
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DR EMBL; BX284601; CAB01695.1; -; Genomic_DNA.
DR EMBL; BX284601; CAV31771.1; -; Genomic_DNA.
DR PIR; T21336; T21336.
DR RefSeq; NP_001251370.1; NM_001264441.1. [Q93560-1]
DR RefSeq; NP_001251371.1; NM_001264442.1. [Q93560-2]
DR AlphaFoldDB; Q93560; -.
DR SMR; Q93560; -.
DR BioGRID; 38333; 15.
DR IntAct; Q93560; 12.
DR STRING; 6239.F25D7.3a; -.
DR EPD; Q93560; -.
DR PaxDb; Q93560; -.
DR EnsemblMetazoa; F25D7.3a.1; F25D7.3a.1; WBGene00003847. [Q93560-1]
DR EnsemblMetazoa; F25D7.3b.1; F25D7.3b.1; WBGene00003847. [Q93560-2]
DR GeneID; 172917; -.
DR KEGG; cel:CELE_F25D7.3; -.
DR UCSC; F25D7.3; c. elegans. [Q93560-1]
DR CTD; 172917; -.
DR WormBase; F25D7.3a; CE09631; WBGene00003847; blmp-1. [Q93560-1]
DR WormBase; F25D7.3b; CE43409; WBGene00003847; blmp-1. [Q93560-2]
DR eggNOG; KOG2461; Eukaryota.
DR GeneTree; ENSGT00940000154798; -.
DR HOGENOM; CLU_018020_0_0_1; -.
DR InParanoid; Q93560; -.
DR OMA; RCPCAYL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q93560; -.
DR SignaLink; Q93560; -.
DR PRO; PR:Q93560; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003847; Expressed in embryo and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0007568; P:aging; IMP:UniProtKB.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0043053; P:dauer entry; IMP:UniProtKB.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:0040035; P:hermaphrodite genitalia development; IMP:UniProtKB.
DR GO; GO:1903355; P:negative regulation of distal tip cell migration; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:1904747; P:positive regulation of apoptotic process involved in development; IMP:WormBase.
DR GO; GO:0045684; P:positive regulation of epidermis development; IMP:UniProtKB.
DR GO; GO:0110039; P:positive regulation of nematode male tail tip morphogenesis; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd19187; PR-SET_PRDM1; 1.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR044413; PRDM1_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..817
FT /note="B lymphocyte-induced maturation protein 1 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000430670"
FT DOMAIN 103..241
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT ZN_FING 508..530
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 592..614
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 620..642
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 685..700
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_057061"
SQ SEQUENCE 817 AA; 88639 MW; 4B74F5263A9594FA CRC64;
MGQGSGDDGV PPAPFSSAAA AAHSPPHSPL SVGVSSASSA TSSSSTPPSS TSPAGVSASG
ARNVETDWKQ SGDENLAELC IFHVPDKSVS LPNPKRAECT LPMNLILKSS SKNRKKSSIW
SSDHIPRGVR FGPLVGEIRL VDVDTALVCP AEASMAGGGP AQEDVPFDEA PEEWKIYSPS
GGRLNKTICV KDDARSNWMK YVAAAEEEDF QNLVAAQIGN DIYFYTVKKI EANTELSFWF
SRDYARKLNY STRPYVRVRR PATQLIPSAP PASASTAIAS LAETIVAIDY SVKKLIESPI
DTLSTDASSA SDEEMIDVEE QESCTRPVAE VTRPNVIQNP VVRPVATKVN NFPGIPVRLG
NFYASPLVDF KEFMRKSLQL KLVDTSMFVS PVAQTTAAIT ATGGRSGQPI DVQPVLAATA
GAHFGNYAAI YGSQDFQHEL SKPLYTSASP AFGGGGGMGG GFGMGGSAHT SSFHQLPFVN
HSSSSHNDSS FNGVPNYVQQ QENGKTRYAC KDCNKTFGQL SNLKVHVRTH TGERPFKCEI
CTKEFTQLAH LQKHHLVHTG ERPHRCDICD KRFSSTSNLK THLRLHNGQK PYTCDVCDAK
FTQYVHLRLH KRLHANERPY SCGTCGKKYI SPSGLRTHWK TTTCKEEDMK DSMRDDLMDI
KGEIDEGSMS GSGYGNLGIF ENTLNSELKR PLMPIETIYS KYNLPNASLL GQGPSGMQEQ
QAPPPTSQQQ QHMMYGNTMG HMGQGSHLQG PPPPPQHFQM DHSGMQNGGG IPHQHQLIQG
GPSSGSGQQQ HPQHNGIHRL PDLKNPLLPS LGLPHYP
