SYL_HELHP
ID SYL_HELHP Reviewed; 830 AA.
AC Q7VIY7;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Leucine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00049};
DE EC=6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00049};
DE Short=LeuRS {ECO:0000255|HAMAP-Rule:MF_00049};
GN Name=leuS {ECO:0000255|HAMAP-Rule:MF_00049}; OrderedLocusNames=HH_0465;
OS Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=235279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51449 / 3B1;
RX PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA Shen Z., Weber J., Frosch M., Fox J.G.;
RT "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT hepaticus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00049};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00049}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000255|HAMAP-Rule:MF_00049}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017125; AAP77062.1; -; Genomic_DNA.
DR RefSeq; WP_011115307.1; NC_004917.1.
DR AlphaFoldDB; Q7VIY7; -.
DR SMR; Q7VIY7; -.
DR STRING; 235279.HH_0465; -.
DR EnsemblBacteria; AAP77062; AAP77062; HH_0465.
DR KEGG; hhe:HH_0465; -.
DR eggNOG; COG0495; Bacteria.
DR HOGENOM; CLU_004427_0_0_7; -.
DR OMA; TFMVLAP; -.
DR OrthoDB; 32262at2; -.
DR Proteomes; UP000002495; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.620; -; 2.
DR HAMAP; MF_00049_B; Leu_tRNA_synth_B; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002302; Leu-tRNA-ligase.
DR InterPro; IPR025709; Leu_tRNA-synth_edit.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR PANTHER; PTHR43740; PTHR43740; 2.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR Pfam; PF13603; tRNA-synt_1_2; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR00985; TRNASYNTHLEU.
DR SUPFAM; SSF47323; SSF47323; 1.
DR SUPFAM; SSF50677; SSF50677; 1.
DR TIGRFAMs; TIGR00396; leuS_bact; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT CHAIN 1..830
FT /note="Leucine--tRNA ligase"
FT /id="PRO_0000152025"
FT MOTIF 48..58
FT /note="'HIGH' region"
FT MOTIF 596..600
FT /note="'KMSKS' region"
FT BINDING 599
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00049"
SQ SEQUENCE 830 AA; 95681 MW; CC08CB32DA94E06F CRC64;
MQERKYNPKD IESKWQQFWT EHKSFEPFDI DIATSDSMKK KYILSMFPYP SGAIHMGHVR
NYCIGDALAR NYRQNGYNVL HPMGWDAFGM PAENAAIKHK THPKTWTYSN IDTMRKELAT
LGLSFSKERE FATSDAIYTR FEQEFFIKMW ERGLIYRKEA YLNWCPKDKT ILANEQVIEG
KCWRCDTPVV QKQMFQYYIK ITDYADELLE CLNKLEGHWP SQVLSMQRNW IGKSKGLSFT
FDFSVDSLQK LGNGKVKLEV FTTRPDTIYG VTYCAVAPEH PIVQQLIENK SLDESVIKSI
EAIKNTTARA RAMSEKVGFD LGVYVIHPLT QEKLPVWVAN FVLMDYGSGA VMSVPMHDER
DFEFAKTYAL PFKCVLTKEI DGEEPTQEIC AAYEEGFLIN SGEFSGMSSS QAKERIIAHF
ENASIGKGIT NYRLRDWGVS RQRYWGAPIP MVHCQSCGIV PEKIENLPIT LPEDVVIDGE
GNPLDKHLVW KDCLCPKCGK KAQRESDTMD TFIQSSWYFL RYSTPRKLWE KQAFDKESLT
YWLNVDEYIG GIEHAILHLL YARFWTKVLR DLGYIEIDEP FANLLTQGMV LKDGAKMSKS
KGNIVNPNEL IAHYGADTAR LFVLFAAPPT RELEWNDKAV EGAHRFLKRL WERAEHIESC
TQKPHINHKT LQKNEQYARQ KVYEALQKSN EIFSKKQSGY AFNTLIAASM EAFNALNEQE
NPLVWTEGYF VLLHILEPIV PHICWELSEQ YFRRCNFAPL SVDKDALTKE SVIYAITING
KKRAEVEMPL GLSKEEIIIQ AKESVPKWLE GVEILKEIIV PNKLVNLVVK