ID   BLO11_PSEAI             Reviewed;         266 AA.
AC   Q06778;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Beta-lactamase OXA-11;
DE            EC=3.5.2.6;
DE   Flags: Precursor;
GN   Name=bla; Synonyms=oxa11;
OS   Pseudomonas aeruginosa.
OG   Plasmid pMLH52.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ABD;
RX   PubMed=8215276; DOI=10.1128/aac.37.8.1637;
RA   Hall L.M.C., Livermore D.M., Gur D., Akova M., Akalin H.E.;
RT   "OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from
RT   Pseudomonas aeruginosa.";
RL   Antimicrob. Agents Chemother. 37:1637-1644(1993).
CC   -!- FUNCTION: Hydrolyzes carbenicillin, oxacillin and cephalosporin. Does
CC       not hydrolyze cefoxitin or carbapenems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10103};
CC   -!- SIMILARITY: Belongs to the class-D beta-lactamase family.
CC       {ECO:0000305}.
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DR   EMBL; Z22590; CAA80304.1; -; Genomic_DNA.
DR   PIR; S33163; S33163.
DR   RefSeq; WP_063860939.1; NG_049402.1.
DR   AlphaFoldDB; Q06778; -.
DR   SMR; Q06778; -.
DR   KEGG; ag:CAA80304; -.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR002137; Beta-lactam_class-D_AS.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
DR   PROSITE; PS00337; BETA_LACTAMASE_D; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Hydrolase; Plasmid; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..266
FT                   /note="Beta-lactamase OXA-11"
FT                   /id="PRO_0000017031"
FT   ACT_SITE        67
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10103"
FT   BINDING         205..207
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         70
FT                   /note="N6-carboxylysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   266 AA;  29538 MW;  01C3B2FC04A6027C CRC64;
     MKTFAAYVII ACLSSTALAG SITENTSWNK EFSAEAVNGV FVLCKSSSKS CATNDLARAS
     KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK QWERDLTLRG AIQVSAVPVF
     QQIAREVGEV RMQKYLKKFS YGSQNISGGI DKFWLEDQLR ISAVNQVEFL ESLYLNKLSA
     SKENQLIVKE ALVTEAAPEY LVHSKTGFSG VGTESNPGVA WWVGWVEKET EVYFFAFNMD
     IDNESKLPLR KSIPTKIMES EGIIGG