ID   BLO19_PSEAI             Reviewed;         266 AA.
AC   Q9R976;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Beta-lactamase OXA-19;
DE            EC=3.5.2.6;
DE   AltName: Full=Penicillinase;
DE   Flags: Precursor;
GN   Name=bla; Synonyms=oxa19;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAe191;
RX   PubMed=9835500; DOI=10.1128/aac.42.12.3113;
RA   Mugnier P., Casin I., Bouthors A.T., Collatz E.;
RT   "Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or
RT   in vitro.";
RL   Antimicrob. Agents Chemother. 42:3113-3116(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10103};
CC   -!- SIMILARITY: Belongs to the class-D beta-lactamase family.
CC       {ECO:0000305}.
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DR   EMBL; AF043381; AAD02245.1; -; Genomic_DNA.
DR   RefSeq; WP_063861309.1; NZ_RJAG01000026.1.
DR   AlphaFoldDB; Q9R976; -.
DR   SMR; Q9R976; -.
DR   KEGG; ag:AAD02245; -.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR002137; Beta-lactam_class-D_AS.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
DR   PROSITE; PS00337; BETA_LACTAMASE_D; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Hydrolase; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..266
FT                   /note="Beta-lactamase OXA-19"
FT                   /id="PRO_0000313799"
FT   ACT_SITE        67
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10103"
FT   BINDING         205..207
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         70
FT                   /note="N6-carboxylysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   266 AA;  29449 MW;  E8EBBA429B3F6008 CRC64;
     MKTFAAYVIT ACLSSTALAS SITENTSWNK EFSAEAVNGV FVLCKSSSKS CATNNLARAS
     KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK QWERDLSLRG AIQVSAVPVF
     QQIAREVGEV RMQKYLKKFS YGNQNISGGI DKFWLEDQLR ISAVNQVEFL ESLFLNKLSA
     SKENQLIVKE ALVTEAAPEY LVHSKTGFSG VGTESNPGVA WWVGWVEKGT EVYFFAFNMD
     IDNENKLPLR KSIPTKIMAS EGIIGG