ID   BLR38_BRELC             Reviewed;         260 AA.
AC   A0A3B7TNM4;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=RxLR effector protein BLR38 {ECO:0000303|PubMed:30251420};
DE   Flags: Precursor;
GN   Name=BLR38 {ECO:0000303|PubMed:30251420};
OS   Bremia lactucae (Lettuce downy mildew).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Bremia.
OX   NCBI_TaxID=4779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Race Bl:24;
RX   PubMed=30251420; DOI=10.1111/mpp.12751;
RA   Pelgrom A.J.E., Eikelhof J., Elberse J., Meisrimler C.N., Raedts R.,
RA   Klein J., Van den Ackerveken G.;
RT   "Recognition of lettuce downy mildew effector BLR38 in Lactuca serriola
RT   LS102 requires two unlinked loci.";
RL   Mol. Plant Pathol. 20:240-253(2019).
CC   -!- FUNCTION: Secreted effector that triggers a robust hypersensitive
CC       response (HR) in Lactuca serriola LS102. The response to BLN06 was
CC       visible as strong necrosis (PubMed:30251420). Although effector
CC       recognition is frequently associated with single dominant R gene loci,
CC       the recognition of BLR38 requires 2 unlinked loci that display
CC       incomplete dominance (PubMed:30251420). {ECO:0000269|PubMed:30251420}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30251420}. Host
CC       nucleus {ECO:0000305|PubMed:30251420}.
CC   -!- DOMAIN: Has the canonical translocation motif RxLR, but lacks the
CC       canonical EER motif, which characterizes most oomycete effectors
CC       identified so far. {ECO:0000305|PubMed:30251420}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; MG686571; AYE92115.1; -; mRNA.
DR   AlphaFoldDB; A0A3B7TNM4; -.
DR   VEuPathDB; FungiDB:CCR75_005744; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..260
FT                   /note="RxLR effector protein BLR38"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5017735352"
FT   MOTIF           46..49
FT                   /note="RxLR"
FT                   /evidence="ECO:0000305|PubMed:30251420"
FT   MOTIF           136..148
FT                   /note="Nuclear localuization signal (NLS)"
FT                   /evidence="ECO:0000305|PubMed:30251420"
SQ   SEQUENCE   260 AA;  29562 MW;  1AC90EE7BAF83406 CRC64;
     MHCTVFFLLI ACAKSSYGQT RSVSTAKSES KSDEYSYNSD AIDQSRLLRG AVNPVSENMA
     LRKFIFDMPE MLRPEHFEPI FINPAAVKEV IKDYLAYGEA LCGSGYDPRL LALFGVRPTV
     LKQELMKAKG VTLSVMPSSR KRPRALDEVE SEVENFRNVL KDFFIPPTTT NPSKLIPDDI
     ETLVPEHVSA HFNSLVYLMY FAVLHFDSQE LATMSSSVLL KYALQKNLLL REKIESGTLG
     EWERDFRLMR VLNVYKSEQT