ID   BLR40_BRELC             Reviewed;         145 AA.
AC   A0A3B7TLI7;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=RxLR effector protein BLR40 {ECO:0000303|PubMed:30251420};
DE   Flags: Precursor;
GN   Name=BLR40 {ECO:0000303|PubMed:30251420};
OS   Bremia lactucae (Lettuce downy mildew).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Bremia.
OX   NCBI_TaxID=4779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, AND FUNCTION.
RC   STRAIN=Race Bl:24;
RX   PubMed=30251420; DOI=10.1111/mpp.12751;
RA   Pelgrom A.J.E., Eikelhof J., Elberse J., Meisrimler C.N., Raedts R.,
RA   Klein J., Van den Ackerveken G.;
RT   "Recognition of lettuce downy mildew effector BLR38 in Lactuca serriola
RT   LS102 requires two unlinked loci.";
RL   Mol. Plant Pathol. 20:240-253(2019).
CC   -!- FUNCTION: Secreted effector that triggers a robust hypersensitive
CC       response (HR) in Lactuca sativa cv. Design that is resistant to
CC       multiple B.lactucae races, including Bl:24.
CC       {ECO:0000269|PubMed:30251420}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30251420}. Host cell
CC       membrane {ECO:0000269|PubMed:30251420}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:30251420}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; MG686572; AYE92116.1; -; mRNA.
DR   AlphaFoldDB; A0A3B7TLI7; -.
DR   VEuPathDB; FungiDB:CCR75_008983; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Host cell membrane; Host membrane; Membrane; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..145
FT                   /note="RxLR effector protein BLR40"
FT                   /id="PRO_5017738820"
FT   MOTIF           44..58
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:30251420"
SQ   SEQUENCE   145 AA;  16723 MW;  9D555B8FAB608523 CRC64;
     MLLSRAISVV ALLACICCGV HTQDSKADLG TLRTTDSAII TSQRRLRTSV DLVDNEERFR
     WPFQQFFKDR WHRKQIKTYF RDQKDNVSEG LVEQLIARHG LKNVEKVLSE VKFPLAVQIS
     IRKILVNYKG KQAFTRPHLT PADTL