BLRF2_EBVB9
ID BLRF2_EBVB9 Reviewed; 162 AA.
AC P03197; Q777F1;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 23-FEB-2022, entry version 73.
DE RecName: Full=Tegument protein BLRF2;
GN ORFNames=BLRF2;
OS Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX NCBI_TaxID=10377;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=6087149; DOI=10.1038/310207a0;
RA Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA Tuffnell P.S., Barrell B.G.;
RT "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL Nature 310:207-211(1984).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=15534216; DOI=10.1073/pnas.0407320101;
RA Johannsen E., Luftig M., Chase M.R., Weicksel S., Cahir-McFarland E.,
RA Illanes D., Sarracino D., Kieff E.;
RT "Proteins of purified Epstein-Barr virus.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16286-16291(2004).
CC -!- FUNCTION: Plays a role in the inhibition of host innate immune system
CC by targeting the CGAS enzymatic activity which is the principal
CC cytosolic DNA sensor that detects invading viral DNA. Acts by
CC inhibiting CGAS-DNA phase separation: directly binds double-stranded
CC DNA (dsDNA) in a length dependent but sequence independent manner and
CC is able to form DNA-induced phase separation in infected cells. DNA
CC phase separation of ORF52 mediates disruption of liquid-like droplets
CC in which CGAS is activated, thereby preventing CGAS activity.
CC {ECO:0000250|UniProtKB:Q2HR80}.
CC -!- SUBUNIT: Homooligomer; homooligomerizes and binds double-stranded DNA
CC (dsDNA) cooperatively (By similarity). Interacts with host CGAS (By
CC similarity). {ECO:0000250|UniProtKB:Q2HR80}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:15534216}.
CC Host cytoplasm {ECO:0000250|UniProtKB:P0C717}.
CC -!- SIMILARITY: Belongs to the herpesviridae BLRF2 family. {ECO:0000305}.
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DR EMBL; V01555; CAA24852.1; -; Genomic_DNA.
DR EMBL; AJ507799; CAD53416.1; -; Genomic_DNA.
DR PIR; G43041; QQBE19.
DR RefSeq; YP_401666.1; NC_007605.1.
DR SMR; P03197; -.
DR IntAct; P03197; 2.
DR MINT; P03197; -.
DR PRIDE; P03197; -.
DR DNASU; 3783717; -.
DR GeneID; 3783717; -.
DR KEGG; vg:3783717; -.
DR Proteomes; UP000153037; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR008642; Herpes_BLRF2.
DR Pfam; PF05812; Herpes_BLRF2; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA-binding; Host cytoplasm; Host-virus interaction;
KW Inhibition of host innate immune response by virus; Late protein;
KW Reference proteome; Viral immunoevasion; Virion; Virion tegument.
FT CHAIN 1..162
FT /note="Tegument protein BLRF2"
FT /id="PRO_0000116256"
FT REGION 118..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..43
FT /evidence="ECO:0000255"
FT COMPBIAS 137..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 162 AA; 17687 MW; E95CD3B969BFE6D8 CRC64;
MSAPRKVRLP SVKAVDMSME DMAARLARLE SENKALKQQV LRGGACASST SVPSAPVPPP
EPLTARQREV MITQATGRLA SQAMKKIEDK VRKSVDGVTT RNEMENILQN LTLRIQVSML
GAKGQPSPGE GTRPRESNDP NATRRARSRS RGREAKKVQI SD
