BLTR_BACSU
ID BLTR_BACSU Reviewed; 273 AA.
AC P39842;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Multidrug-efflux transporter 2 regulator;
GN Name=bltR; Synonyms=bmr2R, bmtR; OrderedLocusNames=BSU26580;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BD170;
RX PubMed=7608059; DOI=10.1128/jb.177.14.3904-3910.1995;
RA Ahmed M., Lyass L., Markham P.N., Taylor S.S., Vazquez-Laslop N.,
RA Neyfakh A.A.;
RT "Two highly similar multidrug transporters of Bacillus subtilis whose
RT expression is differentially regulated.";
RL J. Bacteriol. 177:3904-3910(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Activates transcription of the blt gene in response to
CC structurally dissimilar drugs.
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DR EMBL; L32599; AAC36943.1; -; Genomic_DNA.
DR EMBL; D84432; BAA12356.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14599.1; -; Genomic_DNA.
DR PIR; I39791; I39791.
DR RefSeq; NP_390535.1; NC_000964.3.
DR RefSeq; WP_003229881.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P39842; -.
DR SMR; P39842; -.
DR STRING; 224308.BSU26580; -.
DR PaxDb; P39842; -.
DR PRIDE; P39842; -.
DR EnsemblBacteria; CAB14599; CAB14599; BSU_26580.
DR GeneID; 937644; -.
DR KEGG; bsu:BSU26580; -.
DR PATRIC; fig|224308.179.peg.2888; -.
DR eggNOG; COG0789; Bacteria.
DR eggNOG; COG4978; Bacteria.
DR InParanoid; P39842; -.
DR OMA; KQTLFHY; -.
DR PhylomeDB; P39842; -.
DR BioCyc; BSUB:BSU26580-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 3.20.80.10; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR029442; GyrI-like.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR Pfam; PF06445; GyrI-like; 1.
DR Pfam; PF13411; MerR_1; 1.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR SUPFAM; SSF55136; SSF55136; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..273
FT /note="Multidrug-efflux transporter 2 regulator"
FT /id="PRO_0000098108"
FT DOMAIN 8..77
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 11..30
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ SEQUENCE 273 AA; 32173 MW; 8497D9C3CAC828FF CRC64;
MSEDVKKYFT TGEFSKLCRV KKQTLFHYDE IGLFSPEIKK ENGYRYYSYH QFETFQVISL
FKELGVPLKE IKCLIKGKTP DKILHVLKEK SIEIDKKINE LKQLQTILQT KVTLTEQALE
TDFSSISFEY LNEETFMLSR KTLNLPERKY VAAISELIHE VQQYELDEGY PIGGIFAREQ
ILEKDFYNYS YFYIKVKDGA ENINYHVRPK GLYAVGYEIG GNTEEAYRRI IEFIERNGMQ
IGENAYEEYM LDEMVVDGYE NTYAKILLQV KEV
