ID   SYM1_ASHGO              Reviewed;         182 AA.
AC   Q754F0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Protein SYM1;
GN   Name=SYM1; OrderedLocusNames=AFR120C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May be involved in cellular response to stress. Required to
CC       maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; AE016819; AAS53491.1; -; Genomic_DNA.
DR   RefSeq; NP_985667.1; NM_211021.1.
DR   AlphaFoldDB; Q754F0; -.
DR   STRING; 33169.AAS53491; -.
DR   EnsemblFungi; AAS53491; AAS53491; AGOS_AFR120C.
DR   GeneID; 4621914; -.
DR   KEGG; ago:AGOS_AFR120C; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   HOGENOM; CLU_049109_8_1_1; -.
DR   InParanoid; Q754F0; -.
DR   OMA; KGWEDFE; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006067; P:ethanol metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..182
FT                   /note="Protein SYM1"
FT                   /id="PRO_0000234405"
FT   TRANSMEM        51..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   182 AA;  20670 MW;  C647C7DE8B66901A CRC64;
     MSSFFKFYKA SLQSHPKRTN ALTTGFLFGL GDIVAQTQFP EPGASYDPMR TLRPFLYGAV
     LFSLVGDKWY RFLSTVRLGR LPQAHWANVL ARVACDQLIF APIGVPLYYT AMALMEGGSL
     EDVRIRLSEK WWSTLLANWI VWPAFQLCNF SLVPVQHRLL TVNVLSIFWN TYLSYSNSTA
     SS