ID   SYM1_CANAL              Reviewed;         195 AA.
AC   Q59Q43; A0A1D8PHM0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein SYM1;
GN   Name=SYM1; OrderedLocusNames=CAALFM_C206430CA;
GN   ORFNames=CaO19.21, CaO19.7692;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: May be involved in cellular response to stress. Required to
CC       maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; CP017624; AOW27648.1; -; Genomic_DNA.
DR   RefSeq; XP_711828.1; XM_706736.1.
DR   AlphaFoldDB; Q59Q43; -.
DR   STRING; 237561.Q59Q43; -.
DR   GeneID; 3646558; -.
DR   KEGG; cal:CAALFM_C206430CA; -.
DR   CGD; CAL0000199251; orf19.7692.
DR   VEuPathDB; FungiDB:C2_06430C_A; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   HOGENOM; CLU_049109_8_1_1; -.
DR   InParanoid; Q59Q43; -.
DR   OMA; KGWEDFE; -.
DR   OrthoDB; 1324608at2759; -.
DR   PRO; PR:Q59Q43; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Protein SYM1"
FT                   /id="PRO_0000234408"
FT   TRANSMEM        17..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  23132 MW;  D4F22F976FAA8DC3 CRC64;
     MKYIFNRYNA LLLRRPLITN MITTGLLVGG GDALAQFFFP NNDNNNLEQQ PFDYLRNLRA
     IIYGSLIFAP IGDKWYKFLN TKVVWTRNAQ KPQYQRSMST LLRVMVDQLV FAPFIGIPLY
     YSSMTILENR QPFLDNIIDK FNTSWWITLK SNWLVWPLFQ FFNFYLLPVQ FRLLAVNIIS
     IGWNTYLSYV MHSQK