ID   SYM1_CANGA              Reviewed;         210 AA.
AC   Q6FXJ3;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Protein SYM1;
GN   Name=SYM1; OrderedLocusNames=CAGL0B03465g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in cellular response to stress. Required to
CC       maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR380948; CAG58022.1; -; Genomic_DNA.
DR   RefSeq; XP_445122.1; XM_445122.1.
DR   AlphaFoldDB; Q6FXJ3; -.
DR   STRING; 5478.XP_445122.1; -.
DR   EnsemblFungi; CAG58022; CAG58022; CAGL0B03465g.
DR   GeneID; 2886647; -.
DR   KEGG; cgr:CAGL0B03465g; -.
DR   CGD; CAL0127080; CAGL0B03465g.
DR   VEuPathDB; FungiDB:CAGL0B03465g; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   HOGENOM; CLU_049109_8_1_1; -.
DR   InParanoid; Q6FXJ3; -.
DR   OMA; KGWEDFE; -.
DR   Proteomes; UP000002428; Chromosome B.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006067; P:ethanol metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..210
FT                   /note="Protein SYM1"
FT                   /id="PRO_0000234409"
FT   TRANSMEM        22..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23923 MW;  E352D036045779A7 CRC64;
     MIRLFQLYEH QLKVRPKLTN SIMTGALFGI GDVSAQLLFP SGPDTLPPSA QTNDVKRGKY
     DIPRTVRAVV YGSMIFSFIG DRWYRFLTKV KFSNKPAKHW SNMVLRVCVD QLGFAPLGLP
     FYFGCMSLLE GHGLGAAREK IKLQWWDTLK TNWCVWPLFQ MVNFSLVPLQ HRLLAANVVA
     IFWNTFLSYT NSQIPVGGHK LTVQYPPTVQ