SYM1_CRYNB
ID SYM1_CRYNB Reviewed; 190 AA.
AC P0CQ39; Q55Z20; Q5KND6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=Protein SYM1;
GN Name=SYM1; OrderedLocusNames=CNBA6670;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: May be involved in cellular response to stress. Required to
CC maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; AAEY01000005; EAL22898.1; -; Genomic_DNA.
DR RefSeq; XP_777545.1; XM_772452.1.
DR AlphaFoldDB; P0CQ39; -.
DR EnsemblFungi; AAW41425; AAW41425; CNA06860.
DR EnsemblFungi; EAL22898; EAL22898; CNBA6670.
DR GeneID; 4933932; -.
DR KEGG; cnb:CNBA6670; -.
DR VEuPathDB; FungiDB:CNBA6670; -.
DR HOGENOM; CLU_049109_8_1_1; -.
DR Proteomes; UP000001435; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006067; P:ethanol metabolic process; IEA:EnsemblFungi.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266; PTHR11266; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..190
FT /note="Protein SYM1"
FT /id="PRO_0000410229"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 190 AA; 21318 MW; CAE9FE399C412A20 CRC64;
MAGLMGKYAA FLTRRPVLGN MISSAVLFGT GDVIAQQLIE KKGADHDLPR TARIVTWGGI
LFAPTVNLWF RTLERIPIRS RWPATFARVG LDQFGFAPVI LSGFFTAMTF MEGKDFNAAK
VKWHESFFPT LQANWMLFIP FQILNMGLVP LQYRLLAVNA VNIPWNAFLS LQNAKGRKAE
EDPVAISKKE