ID   SYM1_CRYNJ              Reviewed;         190 AA.
AC   P0CQ38; Q55Z20; Q5KND6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Protein SYM1;
GN   Name=SYM1; OrderedLocusNames=CNA06860;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: May be involved in cellular response to stress. Required to
CC       maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW41425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AE017341; AAW41425.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_567244.1; XM_567244.1.
DR   AlphaFoldDB; P0CQ38; -.
DR   STRING; 5207.AAW41425; -.
DR   PaxDb; P0CQ38; -.
DR   EnsemblFungi; AAW41425; AAW41425; CNA06860.
DR   VEuPathDB; FungiDB:CNA06860; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   InParanoid; P0CQ38; -.
DR   OrthoDB; 1324608at2759; -.
DR   Proteomes; UP000002149; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006067; P:ethanol metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..190
FT                   /note="Protein SYM1"
FT                   /id="PRO_0000234410"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   190 AA;  21318 MW;  CAE9FE399C412A20 CRC64;
     MAGLMGKYAA FLTRRPVLGN MISSAVLFGT GDVIAQQLIE KKGADHDLPR TARIVTWGGI
     LFAPTVNLWF RTLERIPIRS RWPATFARVG LDQFGFAPVI LSGFFTAMTF MEGKDFNAAK
     VKWHESFFPT LQANWMLFIP FQILNMGLVP LQYRLLAVNA VNIPWNAFLS LQNAKGRKAE
     EDPVAISKKE