SYM1_DEBHA
ID SYM1_DEBHA Reviewed; 206 AA.
AC Q6BMY0;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Protein SYM1;
GN Name=SYM1; OrderedLocusNames=DEHA2F01760g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: May be involved in cellular response to stress. Required to
CC maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; CR382138; CAG88747.1; -; Genomic_DNA.
DR RefSeq; XP_460440.1; XM_460440.1.
DR AlphaFoldDB; Q6BMY0; -.
DR STRING; 4959.XP_460440.1; -.
DR EnsemblFungi; CAG88747; CAG88747; DEHA2F01760g.
DR GeneID; 2903848; -.
DR KEGG; dha:DEHA2F01760g; -.
DR VEuPathDB; FungiDB:DEHA2F01760g; -.
DR eggNOG; KOG1944; Eukaryota.
DR HOGENOM; CLU_049109_8_1_1; -.
DR InParanoid; Q6BMY0; -.
DR OMA; KGWEDFE; -.
DR OrthoDB; 1324608at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266; PTHR11266; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..206
FT /note="Protein SYM1"
FT /id="PRO_0000234411"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 23861 MW; 7179F70154622798 CRC64;
MASIYQKYSQ LIAKRPLITN IITTGFLFGS GDYLAQTLYP SSSKYDYKRT LRATFYGSII
FAPIGDKWYR LLHKINFPFP KTKVSPTVSK VLNTLTKVGV DQLVFAPFIG IPLYYSVMSV
LEFHDNPLQV AREKLHAHWF NTLKTNWVVW PTFQLFNFAL IPVQFRLLVV NIFSIGWNCY
LSSVLNHKHD FLIENITDVD KDEILI
