ID   SYM1_KLULA              Reviewed;         195 AA.
AC   Q6CIY7;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Protein SYM1;
GN   Name=SYM1; OrderedLocusNames=KLLA0F22924g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in cellular response to stress. Required to
CC       maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382126; CAG98810.1; -; Genomic_DNA.
DR   RefSeq; XP_456102.1; XM_456102.1.
DR   AlphaFoldDB; Q6CIY7; -.
DR   STRING; 28985.XP_456102.1; -.
DR   EnsemblFungi; CAG98810; CAG98810; KLLA0_F22924g.
DR   GeneID; 2895360; -.
DR   KEGG; kla:KLLA0_F22924g; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   HOGENOM; CLU_049109_8_1_1; -.
DR   InParanoid; Q6CIY7; -.
DR   OMA; TYLSWKT; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006067; P:ethanol metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Protein SYM1"
FT                   /id="PRO_0000234413"
FT   TRANSMEM        21..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  22045 MW;  3E4660091008C677 CRC64;
     MNGFVNWYTA SVKRSPRLTN GIMTGSLFGI GDVIAQVGFP EKKGQKYDLA RTVRAVVYGS
     LIFSIIGDSW YKFLNQKVIV KPGKHWTNTA ARVGCDQLLF APVGIPMYYG VMSILEGKSL
     VDAKKKIEDN WWPTLVTNWY VWPAFQLINF SLVPVHHRLF SVNIISIFWN AFLSFKNSIS
     PSDKKVPVNF PPVPE