ID   SYM1_YARLI              Reviewed;         202 AA.
AC   Q6CAW5;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Protein SYM1;
GN   Name=SYM1; OrderedLocusNames=YALI0C23815g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in cellular response to stress. Required to
CC       maintain mitochondrial DNA (mtDNA) integrity and stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382129; CAG82519.1; -; Genomic_DNA.
DR   RefSeq; XP_502197.1; XM_502197.1.
DR   AlphaFoldDB; Q6CAW5; -.
DR   STRING; 4952.CAG82519; -.
DR   EnsemblFungi; CAG82519; CAG82519; YALI0_C23815g.
DR   GeneID; 2909597; -.
DR   KEGG; yli:YALI0C23815g; -.
DR   VEuPathDB; FungiDB:YALI0_C23815g; -.
DR   HOGENOM; CLU_049109_4_2_1; -.
DR   InParanoid; Q6CAW5; -.
DR   OMA; TYLSWKT; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006067; P:ethanol metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..202
FT                   /note="Protein SYM1"
FT                   /id="PRO_0000234416"
FT   TRANSMEM        15..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  23145 MW;  18761613C66FA32D CRC64;
     MNWYVRLLQK YPYRMAVTST SSLFMIGDCV SQRYFSDKPY EPMRTARAGI YACAFAPAMT
     AWFRFLGQQQ LPVIAKVAID QAVFAPSSIG YYFSVMGLLE GKSPDTIWQS LKNQYWDTLK
     CGWMIWPAFQ LFNFGIVPPN FRVLASNCCG LVWNTFLAYQ NANKMEKGHV ADLVIEEVKE
     EVKEVKQEVL AEVKVIKGFV KQ