ID   SYM2_CAEBR              Reviewed;         634 AA.
AC   A8WPC5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=RNA-binding protein sym-2;
DE   AltName: Full=Synthetic lethal with mec-8 protein 2;
GN   Name=sym-2; ORFNames=CBG00908;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: mRNA splicing factor that regulates alternative splicing of
CC       many genes in embryo. Probably plays a role in the formation of embryo-
CC       specific isoforms (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESRP family. {ECO:0000305}.
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DR   EMBL; HE600951; CAP22331.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WPC5; -.
DR   SMR; A8WPC5; -.
DR   STRING; 6238.CBG00908; -.
DR   WormBase; CBG00908; CBP48136; WBGene00024223; Cbr-sym-2.
DR   eggNOG; KOG1365; Eukaryota.
DR   HOGENOM; CLU_008009_2_2_1; -.
DR   InParanoid; A8WPC5; -.
DR   OMA; HRQVIGQ; -.
DR   OrthoDB; 863041at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..634
FT                   /note="RNA-binding protein sym-2"
FT                   /id="PRO_0000370634"
FT   DOMAIN          285..363
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          395..479
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   634 AA;  71014 MW;  33044E92E7C91A10 CRC64;
     MNRQTSLPEQ RQLLIRVSDS NYDENTKLVV TTFYTSSEDA NNNNATSSYH NISTHFVNIT
     PDDVCKFFDE NPTQSIIFAK GAEPIRHVLI PLFVSNERYV PHQIHQYYDI QHLYYKGGVE
     DENQMEEEDV DVAAEDDVAI ARAIMEMSEE TQCVSSSGVS SLLIFESLYF GSQIWVQLSK
     KIRKESFSPP PPPPLACLHG HPSPYIPVAL CQPPSMGVKE LPLDGMASIF SNYQPRKKIR
     AKFILSIFRP NFWSVLNKKA NGKIRKKPFL CSSAEAMDFV SANAVIVRMR GLPYDCTDTQ
     IRAFFEPLKL TEKILFITRT DGRPTGNCDA FVQFETEEDA QQGLLKHRQV IGQRYIELFK
     STAAEVQQVV KRCNLINSAP VVANAVEVSD EKKKDCVRLR GLPYEATVQH IVNFLGDFAN
     MVKFQGVHMV YNNQGNPSGE AFIQMISEQA AAATASGVHN NFMCVGKKKR YIEVFQSSAE
     ELNLQHLVHQ QQQPQAAPQA LGFLAHLPPP APGAQQIWTS YPSPPISPIL PGQVTQLIIY
     GIHLSIGVPE LVANFTTPDH TVENSFEVQE VMFTRWPTHL CPGEAILTLR SRAVPTQTAQ
     TSPLSQISQI SAYSHHHHPT GLPPNFPLQP ILME