ID   SYME_ECO5E              Reviewed;         113 AA.
AC   B5Z4N0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Endoribonuclease SymE {ECO:0000255|HAMAP-Rule:MF_01193};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01193};
GN   Name=symE {ECO:0000255|HAMAP-Rule:MF_01193};
GN   OrderedLocusNames=ECH74115_5858;
OS   Escherichia coli O157:H7 (strain EC4115 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=444450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC4115 / EHEC;
RX   PubMed=22135463; DOI=10.1073/pnas.1107176108;
RA   Eppinger M., Mammel M.K., Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Genomic anatomy of Escherichia coli O157:H7 outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20142-20147(2011).
CC   -!- FUNCTION: Involved in the degradation and recycling of damaged RNA. It
CC       is itself a target for degradation by the ATP-dependent protease Lon.
CC       {ECO:0000255|HAMAP-Rule:MF_01193}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01193}.
CC   -!- SIMILARITY: Belongs to the SymE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01193}.
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DR   EMBL; CP001164; ACI35501.1; -; Genomic_DNA.
DR   RefSeq; WP_000132630.1; NC_011353.1.
DR   AlphaFoldDB; B5Z4N0; -.
DR   KEGG; ecf:ECH74115_5858; -.
DR   HOGENOM; CLU_151239_0_0_6; -.
DR   OMA; MRQHTRT; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   HAMAP; MF_01193; Endoribonucl_SymE; 1.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR014944; Toxin_SymE-like.
DR   InterPro; IPR020883; TypeI_TA_SymE.
DR   Pfam; PF08845; SymE_toxin; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease; RNA-binding.
FT   CHAIN           1..113
FT                   /note="Endoribonuclease SymE"
FT                   /id="PRO_1000138400"
FT   DOMAIN          29..74
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ   SEQUENCE   113 AA;  12294 MW;  103D9607059B3CD5 CRC64;
     MTDTHSIAQP FEAEVSPANN RQLTVSYASR YPDYSRIPAI TLKGQWLEAA GFATGTVVDV
     KVMEGCIVLT AQPPAAAESE LMQSLRQVCK LSARKQRQVQ EFIGVIAGKQ KVA